The mechanism of circadian clock in the subparaventricular zone by the suprachiasmatic nucleus
Project/Area Number |
23790277
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
Research Institution | Kinki University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 生体リズ / 生物時計 / 視交叉上核 / 組織培養 / 体内時計 / 室傍核下部領域 / 同調 / Per2 |
Research Abstract |
The suprachiasmatic nucleus (SCN) is the circadian center and subparaventricular zone (SPvZ) is the primary relay point of the circadian rhythm delivered from the SCN. Using mPer2promoter::Luciferase knock-in mice, we have found that SPvZ in the cultured brain slice containing SCN generated the bioluminescence rhythm antiphasic to that of the SCN. When SPvZ were culture alone, the bioluminescence rhythm in the SPvZ attenuated immediately, however, afterward co-culture with SCN recovered the rhythm of SPvZ. Now we are utilizing this system and found some requisites to keep the circadian bioluminescence rhythm in the SPvZ.
|
Report
(3 results)
Research Products
(11 results)
-
-
[Journal Article] Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.2013
Author(s)
McCabe MJ, Gaston-Massuet C, Gregory LC, Alatzoglou KS, Tziaferi V, Sbai O, Rondard P, Masumoto KH, Nagano M, Shigeyoshi Y, Pfeifer M, Hulse T, Buchanan CR, Pitteloud N, Martinez-Barbera JP, Dattani MT.
-
Journal Title
J Clin Endocrinol Metab.
Volume: 98(3)
Issue: 3
Pages: E547-E557
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-