Functional analysis of the zinc transporter involved in male fertility.
| Project/Area Number |
23790284
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
FUKUMURA Ryutaro 独立行政法人理化学研究所, 新規変異マウス研究開発チーム, 開発研究員 (90392240)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 亜鉛トランスポーター / 雄性不妊 / ENU / 男性不妊 |
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| Research Abstract |
This study revealed that murine zinc transporter Slc39a6 gene was essential for male fertility. The ENU mutant mice that carried a nonsense mutation on Slc39a6 gene exhibited sterility in male. The testis and spermatozoa morphologies of Slc39a6 mutant mice were normal. By in vitro fertilization, the decreased fertility of their spermatozoa was observed. Slc39a6 gene may act to the sperm fertility.
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Report
(3 results)
Research Products
(8 results)
