| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The aim of this study is to clarify an involvement of glial functions in the somatosensory cortex (S1) in the pathogenesis of neuropathic pain. Using in vivo 2 photon microscopy, I investigated chronologic time-courses of Ca2+ activities in S1 cortical astrocytes both in control and neuropathic pain model animals (SNL; spinal nerve ligation), in parallel with pain behaviors (allodynia). I found that (1) Ca2+ activities in S1 cortex was enhanced by SNL, (2) receptor X was re-awaken in S1 astrocytes, and (3) neuropathic pain was dependent on both (1) and (2). These data strongly suggest that abnormal Ca2+ activities in S1 astrocytes, and subsequent events should be involved in the cause or the development of neuropathic pain.
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