Metabolic regulations by adrenomedullin-RAMP2 system
| Project/Area Number |
23790288
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 生理活性物質 / メタボリックシンドローム |
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| Research Abstract |
Adrenomedullin (AM) is a vasodilating peptide. Receptor activity-modifying protein 2 (RAMP2) is the critical determinant of vascular functions of AM. In high-fat diet fed RAMP2 heterozygous knockout mice and adipocyte-specific RAMP2 knockout mice analysis, these observations indicate that AM-RAMP2 system play critical roles in the regulation of glucose and lipid metabolism and adipocyte development.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Vascular Endothelial Adrenomedullin-RAMP2 System 18 Essential for Vascular Integrity and Organ Homeostasis2013
Author(s)
Teruhide Koyama. Laura Ochoa-Callejero, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Nobuyoshi Iinuma, Takuma Arai, Takahiro Yoshizawa, Yasuhiro Iesato, Yang Lei, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Kyoko Igarashi, Yuichi Tbriyama, Ralf H. Adams, Hayato Kawakami, Naoki Mochizuki, Alfredo Martinez, Takayuki Shindo
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Journal Title
Circulation
Volume: 127
Issue: 7
Pages: 842-853
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel regulation pf cardiac metabolism and homeostasis by the adrenomedullin- receptor activity-modifying protein 2 system2013
Author(s)
Takahiro Yoshizawa, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Yasuhiro Iesato, Teruhide Koyama, Ryuichi Uetake, Lei Yang, Akihiro Yamauchi, Megumu Tanaka, Yuichi Toriyama, Kyoko Igarashi, Tsutomu Nakada, Toshihide Kashihara, Mitsuhiko Yamada, Hayato Kawakami, Hiroki Nakanishi, Ryo Taguchi, Tsuyoshi Nakanishi, Hiroshi Akazawa, Takayuki Shindo
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Journal Title
Hypertension
Volume: 61
Issue: 2
Pages: 341-351
DOI
Related Report
Peer Reviewed
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[Journal Article] Endogenous CGEP protects against neointimal hyperplasia following wire-induced vascular injury2012
Author(s)
Lei Yang, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Takahiro Yoshizawa, Tteruhide Kovama. Yasuhiro Iesato, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Yuichi Toriyama, Kyoko Igarashi, Takayuki Shindo
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Journal Title
Journal of Molecular and Cellular Cardiology
Volume: 59
Pages: 55-56
DOI
Related Report
Peer Reviewed
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