Metabolic regulations by adrenomedullin-RAMP2 system

• Project/Area Number: 23790288
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Shinshu University
• Principal Investigator: KAMIYOSHI Akiko 信州大学, 医学系研究科, 助教 (10397309)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 生理活性物質 / メタボリックシンドローム

Research Abstract

Adrenomedullin (AM) is a vasodilating peptide. Receptor activity-modifying protein 2 (RAMP2) is the critical determinant of vascular functions of AM. In high-fat diet fed RAMP2 heterozygous knockout mice and adipocyte-specific RAMP2 knockout mice analysis, these observations indicate that AM-RAMP2 system play critical roles in the regulation of glucose and lipid metabolism and adipocyte development.

Research Products

• [Journal Article] Vascular Endothelial Adrenomedullin-RAMP2 System 18 Essential for Vascular Integrity and Organ Homeostasis (2013)
  • Author(s): Teruhide Koyama. Laura Ochoa-Callejero, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Nobuyoshi Iinuma, Takuma Arai, Takahiro Yoshizawa, Yasuhiro Iesato, Yang Lei, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Kyoko Igarashi, Yuichi Tbriyama, Ralf H. Adams, Hayato Kawakami, Naoki Mochizuki, Alfredo Martinez, Takayuki Shindo
  • Journal Title: Circulation Volume: 127 Issue: 7 Pages: 842-853
  • DOI: 10.1161/circulationaha.112.000756
  • Peer Reviewed
• [Journal Article] Novel regulation pf cardiac metabolism and homeostasis by the adrenomedullin- receptor activity-modifying protein 2 system (2013)
  • Author(s): Takahiro Yoshizawa, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Yasuhiro Iesato, Teruhide Koyama, Ryuichi Uetake, Lei Yang, Akihiro Yamauchi, Megumu Tanaka, Yuichi Toriyama, Kyoko Igarashi, Tsutomu Nakada, Toshihide Kashihara, Mitsuhiko Yamada, Hayato Kawakami, Hiroki Nakanishi, Ryo Taguchi, Tsuyoshi Nakanishi, Hiroshi Akazawa, Takayuki Shindo
  • Journal Title: Hypertension Volume: 61 Issue: 2 Pages: 341-351
  • DOI: 10.1161/hypertensionaha.111.00647
  • Peer Reviewed
• [Journal Article] Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis (2013)
  • Author(s): Iesato Y, Tanaka M, et al.
  • Journal Title: Am J Pathol. Volume: 182 Issue: 6 Pages: 2380-90
  • DOI: 10.1016/j.ajpath.2013.02.015
  • Peer Reviewed
• [Journal Article] Endogenous CGEP protects against neointimal hyperplasia following wire-induced vascular injury (2012)
  • Author(s): Lei Yang, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Takahiro Yoshizawa, Tteruhide Kovama. Yasuhiro Iesato, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Yuichi Toriyama, Kyoko Igarashi, Takayuki Shindo
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 59 Pages: 55-56
  • DOI: 10.1016/j.yjmcc.2013.02.002
  • Peer Reviewed
• [Journal Article] Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling (2011)
  • Author(s): Takuma Arai, Teuhide Koyama, Takayuki Shindo, et al
  • Journal Title: peptides Volume: Volume32(9) Issue: 9 Pages: 1855-65
  • DOI: 10.1016/j.peptides.2011.07.005
  • Peer Reviewed
• [Journal Article] Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis (2011)
  • Author(s): Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y
  • Journal Title: Current Hypertension Reviews Volume: 7 Pages: 217-27
  • Peer Reviewed
• [Journal Article] Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis (2011)
  • Author(s): Shindo T
  • Journal Title: Current Hypertension Reviews Volume: 7 Pages: 217-227
  • Peer Reviewed
• [Journal Article] Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling (2011)
  • Author(s): Arai T
  • Journal Title: Peptides Volume: 32 Pages: 1855-1865
  • Peer Reviewed
• [Presentation] アドレノメデュリン-RAMP2 システムの代謝制御における意義 (2013)
  • Author(s): 神吉昭子
  • Organizer: 第86回日本内分泌学会
  • Place of Presentation: 仙台
  • Year and Date: 2013-04-25
• [Presentation] Metabolic regulations by adrenomedullin-RAMP2 system (2013)
  • Author(s): 神吉昭子
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-15
• [Presentation] アドレノメデュリン-RAMP2 システムの代謝制御における役割 (2013)
  • Author(s): 神吉昭子
  • Organizer: 第42回日本心脈管作動物質学会
  • Place of Presentation: 奈良
  • Year and Date: 2013-02-08
• [Presentation] Novel metabolic regulations by adrenomedullin-RAMP2 system (2011)
  • Author(s): Kamiyoshi A
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-11-14
• [Presentation] Novel metabolic regulations by adrenomedullin-RAMP2 system (2011)
  • Author(s): 神吉昭子
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-03
• [Presentation] Novel metabolic regulations by adrenomedullin-RAMP2 system (2011)
  • Author(s): Kamiyoshi A
  • Organizer: American Heart Association
  • Place of Presentation: Orland
• [Presentation] アドレノメデュリン-RAMP2システムの代謝制御における役割
  • Author(s): 神吉 昭子
  • Organizer: 日本心脈管作動物質学会
  • Place of Presentation: 奈良県立新公会堂（奈良県）
• [Presentation] Metabolic Regulations by Adrenomedullin-RAMP2 System
  • Author(s): 神吉 昭子
  • Organizer: 日本循環器学会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] アドレノメデュリン-RAMP2システムの代謝制御における意義
  • Author(s): 神吉 昭子
  • Organizer: 日本内分泌学会
  • Place of Presentation: 仙台国際センター（宮城県）
• [Remarks]
  • URL: http://www7a.biglobe.ne.jp/~shindo/