| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Treatment with IFN-β、IL-1β, or TNF-α dose-dependently induced IFITM3 gene expression in cultured astrocytes. Pretreatment with helenalin,an NFκB inhibitor, had no effect on PolyI:C-induced IFITM3 gene epression. In contrast, PolyI:C-induced IFITM3 gene expression was significantly inhibited by pretreatment with BX795, a TBK-1 inhibitor. These results suggest that PolyI:C induces IFITM3 gene expression through TBK-1-IRF3 pathway in cultured astrocytes.
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