Analysis of upstream and downstream signaling of IFITM3

• Project/Area Number: 23790290
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Nagoya University
• Principal Investigator: NAKAJIMA Akira 名古屋大学, 医学系研究科, 講師 (20419237)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: IFITM3 / 神経発達障害 / サイトカイン / 統合失調症 / アストログリア / Toll様受容体 / 神経炎症

Research Abstract

Treatment with IFN-β、IL-1β, or TNF-α dose-dependently induced IFITM3 gene expression in cultured astrocytes. Pretreatment with helenalin,an NFκB inhibitor, had no effect on PolyI:C-induced IFITM3 gene epression. In contrast, PolyI:C-induced IFITM3 gene expression was significantly inhibited by pretreatment with BX795, a TBK-1 inhibitor. These results suggest that PolyI:C induces IFITM3 gene expression through TBK-1-IRF3 pathway in cultured astrocytes.

Research Products

• [Journal Article] Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice (2013)
  • Author(s): Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano SI, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T, Yamada K
  • Journal Title: Glia Volume: 61 Pages: 679-693
  • Peer Reviewed
• [Journal Article] Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice (2013)
  • Author(s): D Ibi, I Nagai, A Nakajima, H Mizoguchi, T Kawase, D Tsuboi, S Kano, Y Sato, M Hayakawa, U. C. Lange, D. J. Adams, M. Azim Surani, T Satoh, A Sawa, K Kaibuchi, T Nabeshima and K Yamada
  • Journal Title: Glia Volume: 61 Issue: 5 Pages: 679-693
  • DOI: 10.1002/glia.22461
  • Peer Reviewed
• [Presentation] 培養アストログリア細胞における Toll 様受容体刺激は神経発達障害関連膜タンパク質IFITM3 の発現を誘導する (2012)
  • Author(s): 中島晶ら
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都
• [Presentation] 神経発達障害に関連する膜タンパク質IFITM3のTLRリガンドによる発現誘導 (2011)
  • Author(s): 中島晶ら
  • Organizer: 第41回日本神経精神薬理学会年会
  • Place of Presentation: 東京
• [Presentation] 神経発達障害に関連する膜タンパク質IFITM3のTLRリガンドによる発現誘導
  • Author(s): 中島晶、衣斐大祐、永井拓、鍋島俊隆、山田清文
  • Organizer: 第４１回日本神経精神薬理学会
  • Place of Presentation: 東京（京王プラザホテル）
• [Presentation] 培養アストログリア細胞におけるToll様受容体刺激は神経発達障害関連膜タンパク質IFITM3の発現を誘導する
  • Author(s): 中島晶、衣斐大祐、永井拓、鍋島俊隆、山田清文
  • Organizer: 第８５回日本薬理学会年会
  • Place of Presentation: 京都国際会館