| Project/Area Number |
23790294
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KANEKO Shuji 京都大学, 大学院・薬学研究科, 教授 (60177516)
NAKAGAWA Takayuki 京都大学, 大学院・薬学研究科, 准教授 (30303845)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脂質メディエーター / スフィンゴシン-1-リン酸 (S1P) / アストロサイト / TRPチャネル / TRPC3 / 細胞内カルシウム動態 / 形態変化 / CXCL1 / S1P / ケモカイン / カルシウム動態 / スフィンゴシン－１ーリン酸 / アラキドン酸 / Ca2+動態 |
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| Research Abstract |
Sphingosine-1-phosphate (S1P) is a biologically active lipid that has an important role in regulating the growth, survival and migration of a variety of cells; however their roles in the brain remain to be elucidated. Transient Receptor Potential Canonical (TRPC) channels, Ca^<2+>-permeable nonselective cation channels, are expressed in astrocytes and involved in Ca^<2+>influx after G-coupled receptor stimulation. In the present study, we demonstrate that S1P-induced Ca^<2+>responses and resultant CXCL1 release can be attributed to TRPC-mediated extracellular Ca^<2+>entry in culturedastrocytes. Further investigations are required to identify the mechanisms of S1P-evoked astrocyte activation
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