Investigation of TBK1 activation mechanism
| Project/Area Number |
23790296
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Nara Institute of Science and Technology (2013)
Osaka University (2011-2012) |
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Principal Investigator |
KAWASAKI Takumi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (60584414)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ホスファチジルイノシトール / 自然免疫 / シグナル伝達 / リン酸化 / ウイルス / イノシトールリン脂質 / PIKfyve / ホスファチジルイノシトール５リン酸 / セリンスレオニンキナーゼ / ウィルス感染 / スクリーニング / TBK1 / IRF3 |
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| Research Abstract |
TBK1 (TANK Binding Kinase 1) is important gene for host defence against virus or microbes infection. Activation mechanism for TBK1 is still unclear. Here we investigated activation mechanism by screening cellular component, and found that Ptdins5P works as signaling mediator for innate immune response during virus infection. Furthermore, synthetic Ptdins5P immunization with antigen induced antigen specific antibody production by TBK1 signaling activation.
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Report
(4 results)
Research Products
(10 results)
