Functional analysis and pathological roles of HIF-1α in vascular remodeling
| Project/Area Number |
23790298
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ISHIZAWA Keisuke 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60398013)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 血管リモデリング / 動脈硬化 / 血管平滑筋細胞 / Hypoxia inducible factor / アンジオテンシン II / アンジオテンシンII |
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| Research Abstract |
It was revealed that Hif-1αis a crucial mediator of angiotensin II (Ang II)-induced vascular remodeling, using mice lacking theHif-1α gene in smooth muscle cells (SMKO mice).
1, Chronic Ang II infusion induced medial thickness and vascular fibrosis in aortae of control mice, but not in SMKO mice.
2, The expression of genes related to fibrosis and inflammation was induced by Ang II in control mice, but not in SMKO mice.
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Report
(3 results)
Research Products
(40 results)
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[Journal Article] Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice2011
Author(s)
Tajima S, Ikeda Y, Sawada K, Yamano N, Horinouchi Y, Kihira Y, Ishizawa K, Izawa-Ishizawa Y, Kawazoe K, Tomita S, Minakuchi K, Tsuchiya K, and Tamaki T
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 302
Issue: 1
Pages: E77-E86
DOI
Related Report
Peer Reviewed
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