the role of renal tubular p21 in diabetic nephropathy
| Project/Area Number |
23790299
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 腎臓 / 糖尿病性腎症 / 細胞老化 / レニン・アンジオテンシン系 / p21 |
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| Research Abstract |
We examined the role of renal senescence in the diabetic kidney. The animal models of diabetes (either type 1 or 2) showed early-onset and time-dependently increased renal senescence through p21-dependent pathway in proximal tubular cells. The senescent diabetic kidney had an increase in TNF-α and immune cells infiltration. The treatment of diabetes reversed the senescent kidney into normal. The results suggest that renal senescence is treatable and could be a new target of diabetic nephropathy.
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Report
(3 results)
Research Products
(10 results)
