ATP/adenosine as a critical link between altered metabolism and neuronal activity
Project/Area Number |
23790303
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
General pharmacology
|
Research Institution | Jikei University School of Medicine |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | アデノシン受容体 / ケトン食療法 / てんかん / 薬理学 / 神経科学 |
Research Abstract |
The “cause-and-effect” relationship between altered metabolism and the neurological conditions are not fully understood yet. We hypothesized that ATP/adenosine might play a specific role in modulating neuronal activity to produce the anticonvulsant effects of the ketogenic diet. We found that ketogenic diet-induced antiseizure effect is caused by ATP release with the subsequent activation of adenosine A_1 receptors.
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Report
(3 results)
Research Products
(16 results)