ATP/adenosine as a critical link between altered metabolism and neuronal activity

• Project/Area Number: 23790303
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: KAWAMURA Masahito 東京慈恵会医科大学, 医学部, 助教 (10408388)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: アデノシン受容体 / ケトン食療法 / てんかん / 薬理学 / 神経科学

Research Abstract

The “cause-and-effect” relationship between altered metabolism and the neurological conditions are not fully understood yet. We hypothesized that ATP/adenosine might play a specific role in modulating neuronal activity to produce the anticonvulsant effects of the ketogenic diet. We found that ketogenic diet-induced antiseizure effect is caused by ATP release with the subsequent activation of adenosine A_1 receptors.

Research Products

• [Journal Article] Adenosine and autism: a spectrum of opportunities (2013)
  • Author(s): Masino SA, Kawamura M, Jr., Cote JL, Williams RB, Ruskin DN
  • Journal Title: Neuropharmacology Volume: 68 Pages: 116-121
  • Peer Reviewed
• [Journal Article] Purines and neuronal excitability: Links to the ketogenic diet. (2012)
  • Author(s): Masino SA, Kawamura M, Jr., Ruskin DN, Geiger JD, Boison D
  • Journal Title: Epilepsy Res Volume: 100 Pages: 229-38
  • Peer Reviewed
• [Journal Article] The relationship between the neuromodulator adenosine and behavioral symptoms of autism (2011)
  • Author(s): Masino SA, Kawamura M, Jr., Plotkin LM, Svedova J, Dimario FJ, Jr., Eigsti IM
  • Journal Title: Neurosci Volume: 500 Pages: 1-5
  • Peer Reviewed
• [Journal Article] A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease (2011)
  • Author(s): Ruskin DN, Ross JL, Kawamura M, Jr., Ruiz TL, Geiger JD, Masino SA
  • Journal Title: Physiol Behav Volume: 103 Pages: 501-507
  • Peer Reviewed
• [Journal Article] Long-term facilitation of spontaneous calcium oscillations in astrocytes with endogenous adenosine in hippocampal slice cultures (2011)
  • Author(s): Kawamura M, Jr., Kawamura M
  • Journal Title: Cell Calcium Volume: 49 Pages: 249-258
  • Peer Reviewed
• [Presentation] Adenosine-mediated inhibition of excitatory transmission during ischemia at different temperatures in the hippocampus. (2013)
  • Author(s): Kawamura M
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-22
• [Presentation] Adenosine-mediated inhibition of excitatory transmission during ischemia at different temperatures in the hippocampus (2013)
  • Author(s): Masahito Kawamura
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
• [Presentation] Metabolism and Purinergic Autocrine Regulation. (ワークショップ) (2012)
  • Author(s): Kawamura M, Jr.
  • Organizer: (ワークショップ) Purine 2012: Adenine Nucleosides and Nucleotides in Biomedicine ～Purinergic Signalling in New Strategy of Drugdiscovery～.
  • Place of Presentation: 福岡
  • Year and Date: 2012-05-31
• [Presentation] Metabolism and Purinergic Autocrine Regulation (2012)
  • Author(s): Masahito Kawamura Jr.
  • Organizer: Purine 2012: Adenine Nucleosides and Nucleotides in Biomedicine ～Purinergic Signalling in New Strategy of Drug Discovery～
  • Place of Presentation: Fukuoka, Ｊａｐａｎ
  • Invited
• [Presentation] アデノシン受容体の活性化を介した海馬アストロサイト自発的カルシウム・オシレーション頻度の長期増強 (2011)
  • Author(s): 川村将仁
  • Organizer: 生理研研究会「情報伝達物質としてのプリンの意義」
  • Place of Presentation: 東岡崎
  • Year and Date: 2011-10-22
• [Presentation] ong-term facilitation of spontaneous astrocytic calcium oscillations with endogenous adenosine in the hippocampus. (2011)
  • Author(s): Kawamura M
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] Long-term facilitation of spontaneous astrocytic calcium oscillations with endogenous adenosine in the hippocampus
  • Author(s): Masahito Kawamura
  • Organizer: 第34回 日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] アデノシン受容体の活性化を介した海馬アストロサイト自発的カルシウム・オシレーション頻度の長期増強
  • Author(s): 川村将仁
  • Organizer: 生理研研究会「情報伝達物質としてのプリンの意義」
  • Place of Presentation: 岡崎コンファレンスセンター（東岡崎）
• [Book] Adenosine and autocrine metabolic regulation of neuronal activity. In:Adenosine: a Key Link between Metabolism and CNS Activity (Masino SA, Boison D, eds) (2012)
  • Author(s): Kawamura M, Jr., Ruskin DN
  • Publisher: New York: Springer.
• [Book] Adenosine: a Key Link between Metabolism and CNS Activity: Adenosine and autocrine metabolic regulation of neuronal activity. (2012)
  • Author(s): Masahito Kawamura
  • Total Pages: 15
  • Publisher: Springer
• [Book] Adenosine and Autism - Recent Research and a New Perspective. In: Autism - A Neurodevelopmental Journal from Genes to Behaviour (Eapan V, ed) (2011)
  • Author(s): Masino SA, Kawamura M, Jr., Svedova J, Dimario FJ, Jr., Eigsti IM.
  • Publisher: Rijeka: InTech