| Project/Area Number |
23790314
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TSUYOSHI Tahara 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員 (20419708)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | トランスローケータープロテイン / 炎症 / 転写 / TSPO / ヘム |
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| Research Abstract |
Since it is known that, during inflammation, TSPO proteins are induced in the inflammation region and TSPO plays a role as an indicator of inflammation, especially within a brain. However, there are many unknown about the induction mechanisms of TSPO gene expression during inflammation. Then, in order to clarify an inflammation-specific transcriptional cis element in TSPO gene, I carried out searching the inflammation responsive element in the upstream region of the mouse and the human TSPO gene.
In the about 1500 bp and 700 bp upstream of a mouse TSPO gene and human TSPO upstream, respectively, these regions could not response against inflammation stimulation such as LPS treatment.
As results, I could find no inflammation responsive element in the about 1500 bp and 700 bp upstream regions in the mouse and human TSPO gene, respectively.
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