Production, release and neuroprotective effect of hydrogen sulfide
| Project/Area Number |
23790316
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | The University of Tokyo (2012)
National Center of Neurology and Psychiatry (2011) |
|---|
Principal Investigator |
MIKAMI Yoshinori 東京大学, 大学院・医学系研究科, 特任研究員 (80532671)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 硫化水素 / カルシウム / ガスメディエータ / 細胞保護 / 神経細胞 / 網膜 / アストロサイト / 生理活性物質 / 薬理学 |
|---|
| Research Abstract |
Hydrogen sulfide (H2S) is produced by 3-mercaptopyruvate sulfurtransferase (3MST) and cysteine aminotransferase (CAT) in the neurons. Thioredoxin and dihydrolipoic acid are required for 3MST to produce H2S. The production of H2S is regulated by calcium (Ca2+); H2S, in turn, regulates Ca2+ influx into photoreceptor cells. H2S protects retinal neurons from light-induced degeneration. H2S can be applied for therapeutic use.
|
Report
(3 results)
Research Products
(32 results)
