• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The elucidation of the humoral immunity control mechanism by heme

Research Project

Project/Area Number 23790320
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionTohoku University

Principal Investigator

MATSUI Miki  東北大学, 大学院・医学系研究科, 助手 (00455784)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords生体分子医学 / 転写因子 / ヘム
Research Abstract

The transcriptional repressor Bach2 possesses the basic region-leucine zipper (bZip) motif that mediates dimer formation with Maf oncoproteins and DNA binding. It has been found that heme inhibits the DNA binding activity of Bach2 in vitro.and induces degradation of Bach2 in B cells. To reveal the molecular mechanism of the heme-mediated regulation of Bach2, we mapped the heme-binding region by using spectroscopic analyses. Moreover, the results of various instrumental analysis of Bach2 revealed that the unstructured region of Bach2 is important for heme binding and/or transducing heme effect upon the functional regulation of Bach2.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results) (of which Invited: 1 results) Book (3 results)

  • [Journal Article] Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach22011

    • Author(s)
      Watanabe-Matsui M
    • Journal Title

      Blood

      Volume: 117 Issue: 20 Pages: 5438-48

    • DOI

      10.1182/blood-2010-07-296483

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2.2011

    • Author(s)
      Watanabe-Matsui M, Muto A, Matsui T, Itoh-Nakadai A, Nakajima O, Murayama K, Yamamoto M, Ikeda-Saito M, Igarashi K.
    • Journal Title

      BLOOD

      Volume: 117 Pages: 5438-5448

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ヘムによる天然変性タンパク質の制御2012

    • Author(s)
      松井(渡部)美紀、村山和隆、松井敏高、齋藤正男、武藤哲彦、五十嵐和彦
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 組換えヘモペキシンを用いた細胞外ヘムによる遺伝子制御機構の解明2012

    • Author(s)
      羽田浩士、白木琢磨、渡部美紀、五十嵐和彦
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] X線小角散乱によるBach2タンパク質の構造変化の解析2012

    • Author(s)
      村山和隆、渡部-松井美紀、松本崇、五十嵐和彦
    • Organizer
      日本蛋白質科学学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Kazuhiko Igarashi Recombinant hemopexin binds heme and induces heme oxygenase-1 expression depending on endocytosis and Bach1 inactivation2012

    • Author(s)
      Hiroshi Hada, Takuma Shiraki, Miki Watanabe
    • Organizer
      7th International Congress on Heme Oxygenases and Related Enzymes, Edinburgh, Scotland
    • Related Report
      2012 Final Research Report
  • [Presentation] Recombinant hemopexin binds heme and induces heme oxygenase-1 expression depending on endocytosis2012

    • Author(s)
      Hiroshi Hada, Takuma Shiraki, Miki Matsui-Watanabe, Kazuhiko Igarashi
    • Organizer
      7th International Congress on Heme Oxygenases and Related Enzymes
    • Place of Presentation
      United Kingdom, Edinburgh
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヘムによる天然変性タンパク質の制御2012

    • Author(s)
      渡部(松井)美紀、村山和隆、松井敏高、齋藤正男、五十嵐和彦
    • Organizer
      第85回 日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Establishment of an experimental system to investigate the mechanism of heme trafficking in endosome2011

    • Author(s)
      羽田浩士、白木琢磨、松井(渡部)美紀 、五十嵐和彦
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] 転写抑制因子Bach2におけるヘム制御ドメインの解析2011

    • Author(s)
      松井(渡部)美紀、村山和隆、松井敏高、齋藤正男、武藤哲彦、五十嵐和彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] 組み換えヘモペキシンを用いたヘム-ヘモペキシン複合体の調製と外来ヘムによる遺伝子制御機構の解明2011

    • Author(s)
      羽田浩士、白木琢磨、松井(渡部)美紀、五十嵐和彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] 転写抑制因子Bach2におけるヘム制御ドメインの解析2011

    • Author(s)
      松井(渡部)美紀、村山和隆、松井敏高、齋藤正男、武藤哲彦、五十嵐和彦
    • Organizer
      第84回 日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 組み換えヘモペキシンを用いたヘム-ヘモペキシン複合体の調製と外来ヘムによる遺伝子制御機構の解明2011

    • Author(s)
      羽田浩士、白木琢磨、松井美紀、五十嵐和彦
    • Organizer
      第84回 日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 栄養ヘムによる遺伝子制御の実験系構築2011

    • Author(s)
      羽田浩士、白木琢磨、渡部美紀、五十嵐和彦
    • Organizer
      第77回日本生化学会東北支部会例会
    • Place of Presentation
      宮城(仙台)
    • Related Report
      2011 Research-status Report
  • [Book] 実験医学、活性酸素・ガス状分子による恒常性制御と疾患2012

    • Author(s)
      武藤哲彦、松井〔渡部〕美紀
    • Publisher
      羊土社
    • Related Report
      2012 Final Research Report
  • [Book] 液性免疫におけるヘムの役割2012

    • Author(s)
      松井美紀
    • Publisher
      東北医学雑誌
    • Related Report
      2012 Final Research Report
  • [Book] 実験医学 活性酸素・ガス状分子による恒常性制御と疾患2012

    • Author(s)
      武藤哲彦 松井(渡部)美紀
    • Publisher
      活性酸素およびヘムによる形質細胞分化の調節
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi