Studies of chromatin architectural protein HMGN3 in pancreaticbeta-cell
| Project/Area Number |
23790323
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | HMGN / クロマチン / 膵β細胞 / 国際情報交流 (米国・NIH) |
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| Research Abstract |
We studied physiological roles of high mobility group N (HMGN) and obtained following results. (1) HMGN3 was highly expressed in pancreatic endocrine cells, and -knockout mouse showed a diabetic phenotype. (2) HMGN3 might interact with a splicing factor. (3) Overexpression of HMGN3 affected the gene expression little in fibroblast but largely in pancreatic beta cell-derived cell. (4) Opposite results were obtained by overexpression of HMGN3 in these cells. HMGN1 interacted with PCNA and facilitated its binding to chromatin.
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Report
(3 results)
Research Products
(6 results)
