Significance of the interferon signal regulation in the maintenance of tissue stem cells
| Project/Area Number |
23790326
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SATO Taku 東京医科歯科大学, 難治疾患研究所, 特任助教 (40375259)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 幹細胞性 / インターフェロン / 造血幹細胞 / 表皮幹細胞 / 幹細胞 |
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| Research Abstract |
In this study, I examined the significance of the interferon signal regulation in the maintenance of epidermal stem cells (EpSCs). As a result, we found that the mice deficient for IRF2, which is a physiological attenuator of type-I IFN signaling, the number of EpSCs decreased with aging in comparison with a control mouse. Combined with the results from lineage tracing studies, it was expected that the premature differentiation of EpSCs was promoted in the environments of excessive IFN signaling.
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Report
(3 results)
Research Products
(3 results)
