Identification of the factor released from apoptotic cells that regulates the gene expressions in macrophages
| Project/Area Number |
23790330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 免疫学 / アポトーシス / 生理活性 / 抗炎症 / アデノシン / 国際情報交流 |
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| Research Abstract |
I found that apoptotic cells released AMP via caspase cleaved-panx1 channel.Furthermore, I revealed that released AMP was converted to adenosine by CD73 on macrophages and, in turn, transduced the immunosuppressive signal to macrophages via adenosine A2 receptors.
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Report
(3 results)
Research Products
(2 results)
