Identification of the factor released from apoptotic cells that regulates the gene expressions in macrophages

Research Project

Project/Area Number	23790330
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General medical chemistry
Research Institution	Kyoto University
Principal Investigator	YAMAGUCHI Hiroshi 京都大学, 大学院・医学研究科, 助教 (10542970)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	免疫学 / アポトーシス / 生理活性 / 抗炎症 / アデノシン / 国際情報交流
Research Abstract	I found that apoptotic cells released AMP via caspase cleaved-panx1 channel.Furthermore, I revealed that released AMP was converted to adenosine by CD73 on macrophages and, in turn, transduced the immunosuppressive signal to macrophages via adenosine A2 receptors.

Report

(3 results)