Function of a novel ER-localized transmembrane lipase-like protein in epidermal barrier formation
| Project/Area Number |
23790334
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
OHGAKI Ryuichi 大阪大学, 大学院・医学系研究科, 助教 (20467525)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | リパーゼ / 表皮バリア / 角質細胞間脂質 / 脂質代謝異常 / 生体分子医学 / 組織形成 / 脂質代謝 |
|---|
| Research Abstract |
Epidermal barrier is crucial for survival of organisms. Homozygous gene disruption of a lipase-like protein LOG1 in mouse is associated with an abnormal water loss from skin and results in lethality at one day post-partum although the detailed mechanism is unknown. This study revealed an augmentation in water permeability and an abnormal lipid composition of stratum corneum in gene knockout mice. It was suggested that LOG1 is a novel transmembrane-type lipase which is involved in the metabolism of intercellular lipids of stratum corneum and is fundamentally important for epidermal barrier.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] NRFL-1, the C. elegans NHERF orthologue, interacts with amino acid transporter 6 (AAT-6) for age-dependent maintenance of AAT-6 on the membrane2012
Author(s)
Hagiwara K, Nagamori S, Umemura YM, Ohgaki R, Tanaka H, Murata D, Nakagomi S, Nomura KH, Kage-Nakadai E, Mitani S, Nomura K, Kanai Y
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Journal Title
Related Report
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[Journal Article] Transport of 3-fluoro-L-alpha-methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PET2012
Author(s)
Wiriyasermkul P, Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, Kitashoji T, Ohgaki R, Tanaka H, Endou H, Endo K, Sakurai H, Kanai Y
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Journal Title
J Nucl Med
Volume: 53
Pages: 1253-1261
Related Report
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[Journal Article] Transport of 3-fluoro-L-α-methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PET.2012
Author(s)
Wiriyasermkul P, Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, Kitashoji T, Ohgaki R, Tanaka H, Endou H, Endo K, Sakurai H, Kanai Y.
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Journal Title
J Nucl Med.
Volume: 53
Issue: 8
Pages: 1253-1261
DOI
Related Report
Peer Reviewed
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[Journal Article] Transport of 3-fluoro-L-alpha-methyl tyrosine by tumor-upregulated amino acid transporter LAT1: a cause of the tumor uptake in PET.2012
Author(s)
Wiriyasermkul P, Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, Kitashoji T, Ohgaki R, Tanaka H, Endou H, Endo K, Sakurai H, Kanai Y.
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Journal Title
Journal of Nuclear Medicine
Volume: in press
Related Report
Peer Reviewed
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