Regulation of lamellipodial dynamics by oscillation of Rac1 activity

• Project/Area Number: 23790335
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Osaka University
• Principal Investigator: YAMAZAKI Daisuke 大阪大学, 微生物病研究所, 助教 (50422415)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 細胞内情報伝達 / シグナル伝達

Research Abstract

It has been reported that Rac, one of Rho-family small GTPase, plays an important role in formation of lamellipodia. However, the regulatory mechanism of Rac activity remains unknown. In this study, it becomes clear that srGAP1 regulates lamellipodial dynamics through the control of Rac activity. The proper control of Rac activity at laemllipodia is important for efficient migration.