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The role of autophagy in osteoarthritis

Research Project

Project/Area Number 23790337
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionKobe University

Principal Investigator

MATSUSHITA Takehiko  神戸大学, 医学部附属病院, 助教 (40467650)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords変形性関節症 / オートファジー / autophagy / chondrocyte / osteoarthritis
Research Abstract

Autophagy is an intracellular self-clearance mechanism. In this study, we hypothesized that autophagy is involved in pathogenesis and progression of osteoarthritis (OA). We conditionally disrupted Atg5, an essential gene for induction of autophagy,in cartilage of mice and analyzed. We also examined the effects of rapamycin, an activator of autophagy against development of OA. Progression of OA induced by destabilization of medial meniscus was accelerated in the cartilage-specific Atg5 knockout mice while progression of OA was delayed by the treatment of rapamycin. Our observation suggests that autophagy plays an important role in pathogenesis and progression of OA.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] マウス変形性関節症モデルにおける徐放化rapamycin投与の関節症進行抑制効果2013

    • Author(s)
      松崎時夫、松下雄彦、高山幸治、松本知之、岡真也、長井寛斗、斎藤高志、田畑泰彦、黒田良祐、黒坂昌弘
    • Organizer
      第28回日本整形外科基礎学術集会
    • Related Report
      2013 Final Research Report
  • [Presentation] Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelle reduces development of experimental osteoarthritis in a murine model2013

    • Author(s)
      Mtsuzaki T, Matsushita T, Tabata Y, Saito T, Matsumoto T, Nagai K, Kurosaka M, Kuroda R
    • Organizer
      2013 World Congress osteoarthritis research international
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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