The role of autophagy in osteoarthritis
| Project/Area Number |
23790337
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 変形性関節症 / オートファジー / autophagy / chondrocyte / osteoarthritis |
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| Research Abstract |
Autophagy is an intracellular self-clearance mechanism. In this study, we hypothesized that autophagy is involved in pathogenesis and progression of osteoarthritis (OA). We conditionally disrupted Atg5, an essential gene for induction of autophagy,in cartilage of mice and analyzed. We also examined the effects of rapamycin, an activator of autophagy against development of OA. Progression of OA induced by destabilization of medial meniscus was accelerated in the cartilage-specific Atg5 knockout mice while progression of OA was delayed by the treatment of rapamycin. Our observation suggests that autophagy plays an important role in pathogenesis and progression of OA.
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Report
(4 results)
Research Products
(2 results)
