Research Project
Grant-in-Aid for Young Scientists (B)
The phagocyte NADPH oxidase, dormant in resting cells, is activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. The catalytic core of the phagocyte oxidase is Nox2/gp91^<phox>, a membrane-spaning protein that forms a stable heterodimer with p22^<phox>. In this study, I found thatboth N-and C-terminal regions play a crucial role in Nox binding to p22^<phox>.Furthermore, I found that the addition of a specific region of nonphagocytic Nox (Nox5) to Nox2 leads to a large amount of Nox2 protein expression.
All 2012 2011
All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (13 results) (of which Invited: 2 results)
Chem. Biol
Volume: 19 Issue: 4 Pages: 488-497
10.1016/j.chembiol.2012.03.008
J. Biol. Chem
Volume: 287 Issue: 21 Pages: 17848-17859
10.1074/jbc.m111.332874
Methods Mol. Biol
Volume: 827 Pages: 195-212
10.1007/978-1-61779-442-1_14
J. Pharmacol. Sci
Volume: 117 Pages: 139-48
https://www.jstage.jst.go.jp/article/jphs/117/3/117_11134FP/_article
J Pharmacol Sci.
Volume: 117 Pages: 139-148
10030453178