Analysis of the molecular mechanisms which underlies the dynamiccharacteristics of regulatory T cell function

• Project/Area Number: 23790346
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Keio University
• Principal Investigator: SEKIYA Takashi 慶應義塾大学, 医学部, 助教 (80519207)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 免疫学 / 細胞分化 / 自己免疫疾患 / 制御性T細胞 / アレルギー / 炎症性疾患 / CD4T細胞

Research Abstract

During their development in the thymus, self-reactive T cells areeither eliminated by apoptosis or differentiated into regulatory T cells. This developmentalsystem plays crucial roles in prevention of autoimmune diseases, however, the underlyingmolecular

Research Products

• [Journal Article] Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis. (2013)
  • Author(s): Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, et al.
  • Journal Title: Nat Immunol. Volume: 14 Issue: 3 Pages: 230-237
  • DOI: 10.1038/ni.2520
  • Peer Reviewed
• [Journal Article] The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells (2011)
  • Author(s): Sekiya, T., et al
  • Journal Title: Nature Communications Volume: 2 Issue: 1 Pages: 269-269
  • DOI: 10.1038/ncomms1272
  • Peer Reviewed
• [Presentation] Regulation of CD4 T cell differentiationand inflammatory diseases by the nuclearorphan receptor Nr4a2 (2012)
  • Author(s): 関谷 高史、吉村 昭彦
  • Organizer: 第41回日本免疫学会学術集会総会
  • Place of Presentation: 神戸
• [Presentation] Roles of the nuclear orphan receptor Nr4a2in regulation of CD4+ T celldifferentiation and inflammatorydiseases (2012)
  • Author(s): Takashi Sekiya and Akihiko Yoshimura
  • Organizer: Keystone Symposia: The Biology of Cytokines
  • Place of Presentation: Colorado (USA)
• [Presentation] Regulation of CD4 T cell differentiation and inflammatory diseases by the nuclear orphan receptor Nr4a2 (2012)
  • Author(s): 関谷 高史
  • Organizer: 第41回日本免疫学会学術集会総会
  • Place of Presentation: 神戸
• [Presentation] Roles of the nuclear orphan receptor Nr4a2 in regulation of CD4 T cell differentiation and inflammatory diseases (2012)
  • Author(s): Takashi Sekiya, Akihiko Yoshimura
  • Organizer: Keystone symposia
  • Place of Presentation: Keystone resort (Colorado, USA)
• [Presentation] 核内オーファン受容体Nr4a2によるCD4T細胞分化と自己免疫疾患の制御 (2011)
  • Author(s): 関谷 高史、吉村 昭彦
  • Organizer: 第40回日本免疫学会学術集会総会
  • Place of Presentation: 千葉
• [Presentation] 核内オーファン受容体Nr4a2によるCD4T細胞分化と自己免疫疾患の制御 (2011)
  • Author(s): 関谷 高史, 吉村 昭彦
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 幕張メッセ（千葉）
• [Book] Nr4a2によるFoxp3の誘導機構臨床免疫・アレルギー、57 巻 (2012)
  • Author(s): 関谷 高史, 吉村 昭彦
  • Publisher: 科学評論社
• [Book] 臨床免疫・アレルギー (2012)
  • Author(s): 関谷 高史
  • Total Pages: 7
  • Publisher: 科学評論社
• [Remarks]
  • URL: http://www.keio.ac.jp/ja/press_release/2011/kr7a43000005s8t8.html