| Project/Area Number |
23790350
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | 滋賀県立成人病センター研究所 (2012)
Research Institute, Shiga Medical Center (2011) |
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Principal Investigator |
TANIGAKI Kenji 滋賀県立成人病センター研究所, 専門研究員 (70362473)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 高次生命医学 / Notch / active avoidance / neuron / RBP-J / striatum / instrumental learning / 転写因子 |
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| Research Abstract |
Notch/RBP-J signaling regulates neural development at multiple stages. We utilized RBP-J conditional knockout mice and found that neuron-specific loss of RBP-J, a main mediator of Notch signaling, causes the deficits in the dopaminergic responsiveness. To elucidate which neural circuit is responsible for Notch -dependent control of Dopaminergic signaling, we examined the sites of Notch signaling activation in the central nervous system.
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