| Project/Area Number |
23790352
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KAWANO Mitsuko 東北大学, 加齢医学研究所, 助教 (90422203)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 金属アレルギー / 遅延型過敏反応 / T細胞受容体レパトア |
|---|
| Research Abstract |
Metal allergy is classified as contact hypersensitivity, which is known as delayed type hypersensitivity. Whereas use of metals as biomaterials is increasing depending on progression of medical technology, patients of metal allergy are also increasing. Mechanisms of metal allergy are under investigation, because identification of antigen presenting cells, effector T cells and antigen peptides of metal allergy have not been carried out comprehensively. Therefore, treatment of metal allergy is only alleviation of inflammation by administration of steroid. In this study, identification of T cell receptor and antigen peptide of metal allergy was focused for development of theoretical basis about prevention and diagnosis for metal allergy.
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