Approach on the molecular mechanism of initiation, progression, and histological typing of gastric cancer from the view of gut differentiation

• Project/Area Number: 23790355
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: YAMAMICHI Nobutake 東京大学, 医学部附属病院, 助教 (30463897)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 胃癌 / 胃腺腫 / 胃癌組織型 / 腸上皮化生 / エピジェネティクス / 消化管分化 / cathepsin E (CTSE) / Cathepsin E / CTSE

Research Abstract

We found that CTSE gene tends to express in sig/por-type gastric cancer (GC) and tend be deficient in tub1/tub2/muc-type GC cell lines. Histologic analyses of surgical specimens showed that CTSE is a marker of both gastric differentiation and sig-type GC. Analyses of endoscopically-resected gastric adenoma and tub1/tub2-type GC showed that more undifferentiated tumors with strong gastric and weak intestinal properties tend to arise from background mucosa with decreased both gastric and intestinal features. In contrast, endoscopically-resected sig-type GC tends to reflect the features of background mucosa.

Research Products

• [Journal Article] Invasion of poorly differentiated adenocarcinoma to the deep muscularis mucosae may be an indicator of lymph node metastasis in Barrett's esophageal cancer. (2013)
  • Author(s): Sakaguchi Y, Ono S, Fujishiro M, Yamamichi N, Koike K
  • Journal Title: Dig Endosc Volume: 25 Pages: 168-172
• [Journal Article] Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis. (2013)
  • Author(s): Konno-Shimizu M, Yamamichi N, Inada K, Kageyama-Yahara N, Shiogama K, Takahashi Y, Asada-Hirayama I, Yamamichi-Nishina M, Nakayama C, Ono S et al
  • Journal Title: PLoS One Volume: 8(2)
• [Journal Article] Evaluation of a new image-enhanced endoscopic technology using band-limited light for detection of esophageal squamous cell carcinoma. (2013)
  • Author(s): Kodashima S, Fujishiro M, Ono S, Niimi K, Mochizuki S, Asada-Hirayama I, Konno-Shimizu M, Matsuda R, Minatsuki C, Nakayama C, Yamamichi N, et al
  • Journal Title: Dig Endosc
• [Journal Article] Factors predictive of inaccurate determination of horizontal extent of intestinal-type early gastric cancers during endoscopic submucosal dissection: A retrospective analysis (2013)
  • Author(s): Asada-Hirayama I, Kodashima S, Goto O, Yamamichi N, Ono S, Niimi K, Mochizuki S, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C et al
  • Journal Title: Dig Endosc
  • NAID: 130005138726
• [Journal Article] Narrow band imaging with magnification can pick up esophageal squamous cell carcinoma more efficiently than lugol chromoendoscopy in patients after chemoradiotherapy. (2013)
  • Author(s): Asada-Hirayama I, Kodashima S, Fujishiro M, Ono S, Niimi K, Mochizuki S, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C, Nakayama C, Yamamichi N, et al
  • Journal Title: Diagn Ther Endosc2013 Volume: 2013 Pages: 256439-256439
• [Journal Article] Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis. (2013)
  • Author(s): Konno-Shimizu M
  • Journal Title: PLoS ONE Volume: 8 Issue: 2 Pages: e56766-e56766
  • DOI: 10.1371/journal.pone.0056766
  • Peer Reviewed
• [Journal Article] Rebamipide induces dendritic cell recruitment to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-exposed rat gastric mucosa based on IL-1beta upregulation. (2012)
  • Author(s): Yamamichi N, Oka M, Inada K, Konno-Shimizu M, Kageyama-Yahara N, Tamai H, Kato J, Fujishiro M, Kodashima S, Niimi K et al
  • Journal Title: Biochem Biophys Res Commun Volume: 424(1) Pages: 124-129
• [Journal Article] Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores. (2012)
  • Author(s): Yamamichi N, Mochizuki S, Asada-Hirayama I, Mikami-Matsuda R, Shimamoto T, Konno-Shimizu M, Takahashi Y, Takeuchi C, Niimi K, Ono S et al
  • Journal Title: BMC Med Volume: 10 Pages: 45-45
• [Journal Article] Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis. (2012)
  • Author(s): Watanabe M, Kato J, Inoue I, Yoshimura N, Yoshida T, Mukoubayashi C, Deguchi H, Enomoto S, Ueda K, Maekita T, Yamamichi N, et al
  • Journal Title: Int J Cancer
• [Journal Article] Magnifying endoscopy with narrow-band imaging helps determine the management of gastric adenomas. (2012)
  • Author(s): Tsuji Y, Ohata K, Sekiguchi M, Ohno A, Ito T, Chiba H, Gunji T, Fukushima J, Yamamichi N, Fujishiro M et al
  • Journal Title: Gastric Cancer Volume: 15(4) Pages: 414-418
• [Journal Article] Evaluation of safetyof endoscopic biopsy without cessation of antithrombotic agents in Japan. (2012)
  • Author(s): Ono S, Fujishiro M, Kodashima S, Takahashi Y, Minatsuki C, Mikami-Matsuda R, Asada-Hirayama I, Konno-Shimizu M, Tsuji Y, Mochizuki S, Yamamichi N, et al
  • Journal Title: J Gastroenterol Volume: 47(7) Pages: 770-774
• [Journal Article] Endoscopic mucosal resection with a ligation device or endoscopic submucosal dissection for rectal carcinoid tumors: an analysis of 24 consecutive cases. (2012)
  • Author(s): Niimi K, Goto O, Fujishiro M, Kodashima S, Ono S, Mochizuki S, Asada-Hirayama I, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C, Yamamichi N, et al
  • Journal Title: Dig Endosc Volume: 24(6) Pages: 443-447
• [Journal Article] Prospective single-arm trial of two-week rabeprazole treatment for ulcer healing after gastric endoscopic submucosal dissection. (2012)
  • Author(s): Niimi K, Fujishiro M, Goto O, Kodashima S, Minatsuki C, Hirayama I, Mochizuki S, Ono S, Yamamichi N, Kakushima N et al
  • Journal Title: Dig Endosc Volume: 24(2) Pages: 110-116
• [Journal Article] Education and Imaging. Gastrointestinal: esophageal hematoma: a rare cause of upper gastrointestinal bleeding. (2012)
  • Author(s): Hirano K, Yamamichi N, Fujishiro M, Koike K
  • Journal Title: J Gastroenterol Hepatol Volume: 27(10) Pages: 1642-1642
• [Journal Article] Discrepancy in diagnosis of gastric submucosal tumor among esophagogastroduodenoscopy, CT, and endoscopic ultrasonography: a retrospective analysis of 93 consecutive cases. (2012)
  • Author(s): Goto O, Kambe H, Niimi K, Mochizuki S, Asada-Hirayama I, Minatsuki C, Ono S, Kodashima S, Yamamichi N, Yamaji Y et al
  • Journal Title: Abdom Imaging Volume: 37(6) Pages: 1074-1078
• [Journal Article] Rebamipide induces dendritic cell recruitment to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-exposed rat gastric mucosa based on IL-1β upregulation (2012)
  • Author(s): Yamamichi N
  • Journal Title: Biochem Biophys Res Commun Volume: 424 Issue: 1 Pages: 124-129
  • DOI: 10.1016/j.bbrc.2012.06.087
  • Peer Reviewed
• [Journal Article] Education and Imaging. Gastrointestinal: esophageal hematoma: a rare cause of upper gastrointestinal bleeding. (2012)
  • Author(s): Hirano K
  • Journal Title: J Gastroenterol Hepatol Volume: 27 Issue: 10 Pages: 1642-1642
  • DOI: 10.1111/j.1440-1746.2012.07228.x
  • Peer Reviewed
• [Journal Article] Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores. (2012)
  • Author(s): Yamamichi N
  • Journal Title: BMC Med Volume: 10 Issue: 1 Pages: 45-45
  • DOI: 10.1186/1741-7015-10-45
  • Peer Reviewed
• [Journal Article] Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis (2012)
  • Author(s): Watanabe M, Kato J, Inoue I, Yoshimura N, Yoshida T, Mukoubayashi C, Deguchi H, Enomoto S, Ueda K, Maekita T, Iguchi M, Tamai H, Utsunomiya H, Yamamichi N, Fujishiro M, Iwane M, Tekeshita T, Mohara O, Ushijima T, Ichinose M
  • Journal Title: Int J Cancer Volume: 131巻 Issue: 11 Pages: 2632-2642
  • DOI: 10.1002/ijc.27514
  • Peer Reviewed
• [Journal Article] Evaluation of safety of endoscopic biopsy without cessation of antithrombotic agents in Japan. (2012)
  • Author(s): Ono S
  • Journal Title: J Gastroenterol Volume: 47 Issue: 7 Pages: 770-774
  • DOI: 10.1007/s00535-012-0538-7
  • Peer Reviewed
• [Journal Article] Postprandial fullness correlates with rapid inflow of gastric content into duodenum but not with chronic gastritis. (2011)
  • Author(s): Yamamichi N, Shimamoto T, Minatsuki C, Yoshida Y, Fujishiro M, Kodashima S, Kato J, Goto O, Ono S, Niimi K et al
  • Journal Title: BMC Gastroenterol Volume: 11 Pages: 140-140
• [Journal Article] An effective training system for endoscopic submucosal dissection of gastric neoplasm. (2011)
  • Author(s): Tsuji Y, Ohata K, Sekiguchi M, Ito T, Chiba H, Gunji T, Yamamichi N, Fujishiro M, Matsuhashi N, Koike K
  • Journal Title: Endoscopy Volume: 43(12) Pages: 1033-1038
• [Journal Article] Postprandial fullness correlates with rapid inflow of gastric content into duodenum but not with chronic gastritis. (2011)
  • Author(s): Yamamichi N, Shimamoto T, Minatsuki C, Yoshida Y, Fujishiro M, Kodashima S, Kato J, Goto O, Ono S, Niimi K, Takahashi Y, Konno-Shimizu M, Ichinose M, Koike K
  • Journal Title: BMC Gastroenterol. Volume: 11 Issue: 1 Pages: 140-140
  • DOI: 10.1186/1471-230x-11-140
  • Peer Reviewed
• [Journal Article] An effective training system for endoscopic submucosal dissection of gastric neoplasm. (2011)
  • Author(s): Tsuji Y, Ohata K, Sekiguchi M, Ito T, Chiba H, Gunji T, Yamamichi N, Fujishiro M, Matsuhashi N, Koike K.
  • Journal Title: Endoscopy Volume: 43 Pages: 1033-1038
  • Peer Reviewed
• [Presentation] コーヒー摂取が上部消化管主要４良性疾患に及ぼす影響の疫学解析 (2013)
  • Author(s): 山道信毅
  • Organizer: 第99回消化器内科学会総会
  • Place of Presentation: 鹿児島
• [Presentation] 早期胃癌・胃腺腫の内視鏡切除検体を用いた、腫瘍部・周囲非腫瘍粘膜部における胃型・腸型マーカーの発現解析 (2012)
  • Author(s): 山道信毅
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 胃印環細胞癌マーカーCathepsin E（CTSE）の同定と臨床検体における発現解析 (2012)
  • Author(s): 今野真己
  • Organizer: JDDW2012
  • Place of Presentation: 神戸
• [Presentation] 胃食道逆流症状に影響する生活背景因子の探索 － FSSGスコアを用いた我が国の健常成人19,864人の横断解析 (2012)
  • Author(s): 山道信毅
  • Organizer: 第17回GERD Award最終選考会
  • Place of Presentation: 東京
  • Invited
• [Presentation] FSSG（Frequency Scale for the Symptoms of GERD）を用いた健常成人19864人の上部消化管症状の解析 (2012)
  • Author(s): 山道信毅
  • Organizer: JDDW2012
  • Place of Presentation: 神戸
• [Presentation] ヘリコバクター・ピロリ感染が胆石発症へ及ぼす影響の解析 (2012)
  • Author(s): 高橋悠
  • Organizer: 第98回消化器病学会総会
  • Place of Presentation: 東京
• [Presentation] 巨大コホートを用いた胃食道逆流症と背景因子の検討 (2012)
  • Author(s): 皆月ちひろ
  • Organizer: 第98回消化器病学会総会
  • Place of Presentation: 東京