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Approach on the molecular mechanism of initiation, progression, and histological typing of gastric cancer from the view of gut differentiation

Research Project

Project/Area Number 23790355
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

YAMAMICHI Nobutake  東京大学, 医学部附属病院, 助教 (30463897)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords胃癌 / 胃腺腫 / 胃癌組織型 / 腸上皮化生 / エピジェネティクス / 消化管分化 / cathepsin E (CTSE) / Cathepsin E / CTSE
Research Abstract

We found that CTSE gene tends to express in sig/por-type gastric cancer (GC) and tend be deficient in tub1/tub2/muc-type GC cell lines. Histologic analyses of surgical specimens showed that CTSE is a marker of both gastric differentiation and sig-type GC. Analyses of endoscopically-resected gastric adenoma and tub1/tub2-type GC showed that more undifferentiated tumors with strong gastric and weak intestinal properties tend to arise from background mucosa with decreased both gastric and intestinal features. In contrast, endoscopically-resected sig-type GC tends to reflect the features of background mucosa.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (31 results)

All 2013 2012 2011

All Journal Article (24 results) (of which Peer Reviewed: 8 results) Presentation (7 results) (of which Invited: 1 results)

  • [Journal Article] Invasion of poorly differentiated adenocarcinoma to the deep muscularis mucosae may be an indicator of lymph node metastasis in Barrett's esophageal cancer.2013

    • Author(s)
      Sakaguchi Y, Ono S, Fujishiro M, Yamamichi N, Koike K
    • Journal Title

      Dig Endosc

      Volume: 25 Pages: 168-172

    • Related Report
      2012 Final Research Report
  • [Journal Article] Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis.2013

    • Author(s)
      Konno-Shimizu M, Yamamichi N, Inada K, Kageyama-Yahara N, Shiogama K, Takahashi Y, Asada-Hirayama I, Yamamichi-Nishina M, Nakayama C, Ono S et al
    • Journal Title

      PLoS One

      Volume: 8(2)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Evaluation of a new image-enhanced endoscopic technology using band-limited light for detection of esophageal squamous cell carcinoma.2013

    • Author(s)
      Kodashima S, Fujishiro M, Ono S, Niimi K, Mochizuki S, Asada-Hirayama I, Konno-Shimizu M, Matsuda R, Minatsuki C, Nakayama C, Yamamichi N, et al
    • Journal Title

      Dig Endosc

    • Related Report
      2012 Final Research Report
  • [Journal Article] Factors predictive of inaccurate determination of horizontal extent of intestinal-type early gastric cancers during endoscopic submucosal dissection: A retrospective analysis2013

    • Author(s)
      Asada-Hirayama I, Kodashima S, Goto O, Yamamichi N, Ono S, Niimi K, Mochizuki S, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C et al
    • Journal Title

      Dig Endosc

    • NAID

      130005138726

    • Related Report
      2012 Final Research Report
  • [Journal Article] Narrow band imaging with magnification can pick up esophageal squamous cell carcinoma more efficiently than lugol chromoendoscopy in patients after chemoradiotherapy.2013

    • Author(s)
      Asada-Hirayama I, Kodashima S, Fujishiro M, Ono S, Niimi K, Mochizuki S, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C, Nakayama C, Yamamichi N, et al
    • Journal Title

      Diagn Ther Endosc2013

      Volume: 2013 Pages: 256439-256439

    • Related Report
      2012 Final Research Report
  • [Journal Article] Cathepsin E Is a Marker of Gastric Differentiation and Signet-Ring Cell Carcinoma of Stomach: A Novel Suggestion on Gastric Tumorigenesis2013

    • Author(s)
      Konno-Shimizu M
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 2 Pages: e56766-e56766

    • DOI

      10.1371/journal.pone.0056766

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rebamipide induces dendritic cell recruitment to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-exposed rat gastric mucosa based on IL-1beta upregulation.2012

    • Author(s)
      Yamamichi N, Oka M, Inada K, Konno-Shimizu M, Kageyama-Yahara N, Tamai H, Kato J, Fujishiro M, Kodashima S, Niimi K et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 424(1) Pages: 124-129

    • Related Report
      2012 Final Research Report
  • [Journal Article] Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores.2012

    • Author(s)
      Yamamichi N, Mochizuki S, Asada-Hirayama I, Mikami-Matsuda R, Shimamoto T, Konno-Shimizu M, Takahashi Y, Takeuchi C, Niimi K, Ono S et al
    • Journal Title

      BMC Med

      Volume: 10 Pages: 45-45

    • Related Report
      2012 Final Research Report
  • [Journal Article] Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis.2012

    • Author(s)
      Watanabe M, Kato J, Inoue I, Yoshimura N, Yoshida T, Mukoubayashi C, Deguchi H, Enomoto S, Ueda K, Maekita T, Yamamichi N, et al
    • Journal Title

      Int J Cancer

    • Related Report
      2012 Final Research Report
  • [Journal Article] Magnifying endoscopy with narrow-band imaging helps determine the management of gastric adenomas.2012

    • Author(s)
      Tsuji Y, Ohata K, Sekiguchi M, Ohno A, Ito T, Chiba H, Gunji T, Fukushima J, Yamamichi N, Fujishiro M et al
    • Journal Title

      Gastric Cancer

      Volume: 15(4) Pages: 414-418

    • Related Report
      2012 Final Research Report
  • [Journal Article] Evaluation of safetyof endoscopic biopsy without cessation of antithrombotic agents in Japan.2012

    • Author(s)
      Ono S, Fujishiro M, Kodashima S, Takahashi Y, Minatsuki C, Mikami-Matsuda R, Asada-Hirayama I, Konno-Shimizu M, Tsuji Y, Mochizuki S, Yamamichi N, et al
    • Journal Title

      J Gastroenterol

      Volume: 47(7) Pages: 770-774

    • Related Report
      2012 Final Research Report
  • [Journal Article] Endoscopic mucosal resection with a ligation device or endoscopic submucosal dissection for rectal carcinoid tumors: an analysis of 24 consecutive cases.2012

    • Author(s)
      Niimi K, Goto O, Fujishiro M, Kodashima S, Ono S, Mochizuki S, Asada-Hirayama I, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C, Yamamichi N, et al
    • Journal Title

      Dig Endosc

      Volume: 24(6) Pages: 443-447

    • Related Report
      2012 Final Research Report
  • [Journal Article] Prospective single-arm trial of two-week rabeprazole treatment for ulcer healing after gastric endoscopic submucosal dissection.2012

    • Author(s)
      Niimi K, Fujishiro M, Goto O, Kodashima S, Minatsuki C, Hirayama I, Mochizuki S, Ono S, Yamamichi N, Kakushima N et al
    • Journal Title

      Dig Endosc

      Volume: 24(2) Pages: 110-116

    • Related Report
      2012 Final Research Report
  • [Journal Article] Education and Imaging. Gastrointestinal: esophageal hematoma: a rare cause of upper gastrointestinal bleeding.2012

    • Author(s)
      Hirano K, Yamamichi N, Fujishiro M, Koike K
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 27(10) Pages: 1642-1642

    • Related Report
      2012 Final Research Report
  • [Journal Article] Discrepancy in diagnosis of gastric submucosal tumor among esophagogastroduodenoscopy, CT, and endoscopic ultrasonography: a retrospective analysis of 93 consecutive cases.2012

    • Author(s)
      Goto O, Kambe H, Niimi K, Mochizuki S, Asada-Hirayama I, Minatsuki C, Ono S, Kodashima S, Yamamichi N, Yamaji Y et al
    • Journal Title

      Abdom Imaging

      Volume: 37(6) Pages: 1074-1078

    • Related Report
      2012 Final Research Report
  • [Journal Article] Rebamipide induces dendritic cell recruitment to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-exposed rat gastric mucosa based on IL-1β upregulation2012

    • Author(s)
      Yamamichi N
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 424 Issue: 1 Pages: 124

    • DOI

      10.1016/j.bbrc.2012.06.087

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Education and Imaging. Gastrointestinal: esophageal hematoma: a rare cause of upper gastrointestinal bleeding.2012

    • Author(s)
      Hirano K
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 27 Issue: 10 Pages: 1642-1642

    • DOI

      10.1111/j.1440-1746.2012.07228.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lifestyle factors affecting gastroesophageal reflux disease symptoms: A cross-sectional study of healthy 19864 adults using FSSG scores2012

    • Author(s)
      Yamamichi N
    • Journal Title

      BMC Med

      Volume: 10 Issue: 1 Pages: 45-45

    • DOI

      10.1186/1741-7015-10-45

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis2012

    • Author(s)
      Watanabe M, Kato J, Inoue I, Yoshimura N, Yoshida T, Mukoubayashi C, Deguchi H, Enomoto S, Ueda K, Maekita T, Iguchi M, Tamai H, Utsunomiya H, Yamamichi N, Fujishiro M, Iwane M, Tekeshita T, Mohara O, Ushijima T, Ichinose M
    • Journal Title

      Int J Cancer

      Volume: 131巻 Issue: 11 Pages: 2632-2642

    • DOI

      10.1002/ijc.27514

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of safety of endoscopic biopsy without cessation of antithrombotic agents in Japan2012

    • Author(s)
      Ono S
    • Journal Title

      J Gastroenterol

      Volume: 47 Issue: 7 Pages: 770

    • DOI

      10.1007/s00535-012-0538-7

    • NAID

      10030962124

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Postprandial fullness correlates with rapid inflow of gastric content into duodenum but not with chronic gastritis.2011

    • Author(s)
      Yamamichi N, Shimamoto T, Minatsuki C, Yoshida Y, Fujishiro M, Kodashima S, Kato J, Goto O, Ono S, Niimi K et al
    • Journal Title

      BMC Gastroenterol

      Volume: 11 Pages: 140-140

    • Related Report
      2012 Final Research Report
  • [Journal Article] An effective training system for endoscopic submucosal dissection of gastric neoplasm.2011

    • Author(s)
      Tsuji Y, Ohata K, Sekiguchi M, Ito T, Chiba H, Gunji T, Yamamichi N, Fujishiro M, Matsuhashi N, Koike K
    • Journal Title

      Endoscopy

      Volume: 43(12) Pages: 1033-1038

    • Related Report
      2012 Final Research Report
  • [Journal Article] Postprandial fullness correlates with rapid inflow of gastric content into duodenum but not with chronic gastritis2011

    • Author(s)
      Yamamichi N, Shimamoto T, Minatsuki C, Yoshida Y, Fujishiro M, Kodashima S, Kato J, Goto O, Ono S, Niimi K, Takahashi Y, Konno-Shimizu M, Ichinose M, Koike K
    • Journal Title

      BMC Gastroenterol.

      Volume: 11 Issue: 1 Pages: 140-140

    • DOI

      10.1186/1471-230x-11-140

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] An effective training system for endoscopic submucosal dissection of gastric neoplasm.2011

    • Author(s)
      Tsuji Y, Ohata K, Sekiguchi M, Ito T, Chiba H, Gunji T, Yamamichi N, Fujishiro M, Matsuhashi N, Koike K.
    • Journal Title

      Endoscopy

      Volume: 43 Pages: 1033-1038

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] コーヒー摂取が上部消化管主要4良性疾患に及ぼす影響の疫学解析2013

    • Author(s)
      山道信毅
    • Organizer
      第99回消化器内科学会総会
    • Place of Presentation
      鹿児島
    • Related Report
      2012 Annual Research Report
  • [Presentation] 早期胃癌・胃腺腫の内視鏡切除検体を用いた、腫瘍部・周囲非腫瘍粘膜部における胃型・腸型マーカーの発現解析2012

    • Author(s)
      山道信毅
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 胃印環細胞癌マーカーCathepsin E(CTSE)の同定と臨床検体における発現解析2012

    • Author(s)
      今野真己
    • Organizer
      JDDW2012
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 胃食道逆流症状に影響する生活背景因子の探索 - FSSGスコアを用いた我が国の健常成人19,864人の横断解析2012

    • Author(s)
      山道信毅
    • Organizer
      第17回GERD Award最終選考会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] FSSG(Frequency Scale for the Symptoms of GERD)を用いた健常成人19864人の上部消化管症状の解析2012

    • Author(s)
      山道信毅
    • Organizer
      JDDW2012
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヘリコバクター・ピロリ感染が胆石発症へ及ぼす影響の解析2012

    • Author(s)
      高橋悠
    • Organizer
      第98回消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 巨大コホートを用いた胃食道逆流症と背景因子の検討2012

    • Author(s)
      皆月ちひろ
    • Organizer
      第98回消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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