Physiological significance of a novel brain-specific lipid mediator production pathway.

Research Project

Project/Area Number	23790356
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pathological medical chemistry
Research Institution	The University of Tokyo
Principal Investigator	KITA Yoshihiro 東京大学, 大学院・医学系研究科, 准教授 (20401028)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	代謝異常学 / 脂質メタボロミクス / 脂質
Research Abstract	MGL-deficient mice and cPLA(2)alpha-deficient mice were subjected to LPS-induced fever model. Febrile response was lost in MGL-deficient mice, suggesting MGL is involved in hypothalamic prostaglandin E2 production during fever.