Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Research Abstract |
We identified HRG/ErbB signaling as a key molecular mechanism on regulating breast cancer stem cell properties. ErbB signaling maintains breast cancer stem cell properties via PI3K/NF-kappaB pathway, suggesting that crosstalk between growth factor signaling and inflammatory response pathway is important for such regulation. Moreover, IGF2 signaling is required for maintenance of the breast cancer stem cell properties as a downstream mediator of PI3K signaling. Also, HRG signature and IGF signature identified by microarray analysis is strongly associated with both breast cancer grade and prognosis such as metastasis or relapse. These observations suggest that these growth factor signaling have important roles on malignant progression of breast cancer through maintenance of breast cancer stem cell properties.
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