The comprehensive analysis of WNK, the causative gene of PHA2, andWNK signaling pathway
| Project/Area Number |
23790358
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SATO Atsushi 東京医科歯科大学, 難治疾患研究所, 助教 (30451925)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | WNK / 偽性低アルドステロン症II型 / ショウジョウバエ(モデル生物) / 偽性低アルドステロン症２型 / モデル生物（ショウジョウバエ） / 偽性低アルドステイン症２型 |
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| Research Abstract |
WNK1 and WNK4 have been linked to a hereditary form of human hypertension known as Pseudohypoaldosteronism type II (PHAII). We identified that the malfunction of this regulation caused PHAII in mouse. However, this misregulation cannot cause all of pathological conditions of PHAII, such as a mental retardation. We already identified Lhx8/Awh as a new downstream target of WNK signaling pathway. For studying the detail mechanism of WNK signaling pathway, we started to screen the interacting factor(s) using Drosophila melanogaster.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] IQGAP1 functions as a modulator of Dishevelled nuclear localization in Wnt signaling2013
Author(s)
Goto, T., Sato, A., Shimizu, M., Adachi, S., Satoh, K., Iemura, S., Natsume, T. and Shibuya, H
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Journal Title
PLoS One
Volume: 8
Issue: 4
Pages: e60865-e60865
DOI
Related Report
Peer Reviewed
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