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Investigation of apoC-III on atherosclerosis

Research Project

Project/Area Number 23790359
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionKobe University (2012)
University of Yamanashi (2011)

Principal Investigator

KOIKE Tomonari  神戸大学, 大学院・医学研究, 助教 (40432158)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords分子病態学 / 動脈硬化 / アポリポ蛋白CIII / トランスジェニックウサギ / ウサギ
Research Abstract

Features of lipoprotein metabolism in rabbits, unlike mouse, resemble to human, we planned to make human apoCIII transgenic (Tg) rabbits to reveal its functions on lipoprotein metabolism and atherogenesis. For the first year, we injected more than 500 embryos but failed to obtain any positiveTg rabbits due to low number of living pups born. After that, we modified the protocol of microinjection. In the second year, we successfully got 48 alive pups. Although we still did not get any positive rabbits that carry human apoCIII gene, it is quite possible that we will be successful soon. The work is under way for the further experiment.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (12 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Human apolipoprotein A-II protects against diet-induced atherosclerosis in transgenic rabbits2013

    • Author(s)
      Wang Y, Niimi M, Nishijima K, Waqar AB, Yu Y, Koike T, Kitajima S, Liu E, Inoue T, Kohashi M, Keyamura Y, Yoshikawa T, Zhang J, Ma L, Zha X, Watanabe T, Asada Y, Chen YE, Fan J
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 33 Pages: 224-231

    • Related Report
      2012 Final Research Report
  • [Journal Article] Human apolipoprotein AII protects against diet-induced atherosclerosis in transgenic rabbits.2013

    • Author(s)
      Wang, Y.
    • Journal Title

      Arterioscler Thromb Vas Biol.

      Volume: 33 Issue: 2 Pages: 224-231

    • DOI

      10.1161/atvbaha.112.300445

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 急性冠症候群誘発モデル、WHHLMIウサギ2012

    • Author(s)
      小池 智也,伊藤 隆,山田 悟士、国吉 信恵、小林 努,塩見 雅志
    • Organizer
      第116回関西実験動物研究会
    • Place of Presentation
      聖護院御殿荘(京都市)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] ApoAII-rich HDLs have anti-inflammatory functions2012

    • Author(s)
      Koike T, Wang Y, Yu Y, Wang X, Niimi M, Waqar AB, Kitajima S, Nishijima K, Fan J
    • Organizer
      XVI International Symposium on Atherosclerosis.
    • Place of Presentation
      Sydney Convention and Exhibition Centre (Sydney)
    • Related Report
      2012 Final Research Report
  • [Presentation] WHHLMI rabbits develop metabolic syndrome when consumed normal-calories-diet containing fat and fructose2012

    • Author(s)
      Yu Y, Ning B, Wang X, Waqar AB, Koike T, Shiomi M, Fan J
    • Organizer
      第44回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Apolipoprotein-AII plays an important role in lipid metabolism2012

    • Author(s)
      Koike T, Kitajima S, Nishijima K, Liu E, Watanabe T, Fan J
    • Organizer
      第1回日中合同ウサギバイオサイエンスフォーラム
    • Place of Presentation
      宮崎観光ホテル(宮崎市)
    • Related Report
      2012 Final Research Report
  • [Presentation] WHHLMI rabbits develop metabolic syndrome when consumed normal-calories-diet containing fat and fructose2012

    • Author(s)
      Yu Y, Ning B, Wang X, Waqar AB, Koike T, Shiomi M, Fan J
    • Organizer
      第44回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Apolipoprotein-AII plays an important role in lipid metabolism2012

    • Author(s)
      Koike T, Kitajima S, Nishijima K, Liu E, Watanabe T, Fan J
    • Organizer
      第1回日中合同ウサギバイオサイエンスフォーラム
    • Place of Presentation
      宮崎観光ホテル(宮崎市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 急性冠症候群誘発モデル、WHHLMIウサギ2012

    • Author(s)
      小池 智也,伊藤 隆,山田 悟士、国吉 信恵、小林 努,塩見 雅志
    • Organizer
      第116回関西実験動物研究会
    • Place of Presentation
      聖護院御殿荘(京都市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ApoAII-rich HDLs have anti-inflammatory functions.2012

    • Author(s)
      Koike T, Wang Y, Yu Y, Wang X, Niimi M, Waqar AB, Kitajima S, Nishijima K, Fan J.
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      Sydney Convention and Exhibition Centre (Sydney)
    • Related Report
      2011 Research-status Report
  • [Presentation] Apolipoprotein-AII plays an important role in lipid metabolism and atherosclerosis2011

    • Author(s)
      Koike T, Kitajima S, Nishijima K, Liu E, Watanabe T, Fan J
    • Organizer
      4th international Rabbit Biotechnology Meeting
    • Place of Presentation
      Hungarian Academy of Sciences (Budapest)
    • Related Report
      2012 Final Research Report
  • [Presentation] Probucol has different anti-atherogenic effects compared to atorvastatin2011

    • Author(s)
      Niimi M, Nozako M, Koyama T, Nagano C, Kohashi M, Okutsu R, Kudo Y, Yoshikawa T, Koike T, Fan J
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Apolipoprotein-AII plays an important role in lipid metabolism and atherosclerosis.2011

    • Author(s)
      Koike T, Kitajima S, Nishijima K, Liu E, Watanabe T, Fan J.
    • Organizer
      4th international Rabbit Biotechnology Meeting
    • Place of Presentation
      Hungarian Academy of Sciences (Budapest)
    • Related Report
      2011 Research-status Report
  • [Presentation] Probucol has different anti-atherogenic effects compared to atorvastatin.2011

    • Author(s)
      Niimi M, Nozako M, Koyama T, Nagano C, Kohashi M, Okutsu R, Kudo Y, Yoshikawa T, Koike T, Fan J.
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2011 Research-status Report
  • [Book] LIPOPROTEINS ROLE IN HEALTH AND DISEASES2012

    • Author(s)
      Shiomi M, Koike T, Ishida T
    • Total Pages
      758
    • Publisher
      INTECH
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.yamanashi.ac.jp/clinical_basic/pathol01/index.html

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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