Elucidation of activation mechanisms for ganglioside-deficient glial cells
| Project/Area Number |
23790361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
OHMI Yuhsuke 名古屋大学, 医学系研究科, 特任助教 (10584758)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アストロサイト / ミクログリア / ニューロン / ガングリオシド / 神経変性 / 炎症 / グリア / アストログリア / ミクロドメイン |
|---|
| Research Abstract |
Gangliosides (acidic glycosphingolipids) expressed on the plasma membrane are highly expressed in nerve tissues of vertebrates, and are involved in their development and functions. Our study clarified that glial cells components of nerve tissues, also express gangliosides on the plasma membrane, and glial cells in gangliosides-deficient mice were abnormally activated in the brain and enhanced sensitivity for inflammatory cytokines.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] C9-R95X Polymorphism in Patients with Neovascular Age-Related Macular Degeneration2012
Author(s)
Koji Nishiguchi, Tetsuhiro Yasuma, Daisuke Tomida, Makoto Nakamura, Kohei Ishikawa, Masato Kikuchi, Yuhsuke Ohmi, Toshimitsu Niwa, Nobuyuki Hamajima, Koichi Furukawa, and Hiroko Terasaki
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 53(1)
Pages: 508-12
Related Report
Peer Reviewed
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[Journal Article] Functional activation of Src family kinase Yes is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD32011
Author(s)
Hamamura, K., Tsuji, M., Hotta, H., Ohkawa, Y., Takahashi, M., Shibuya, H., Nakashima, H., Yamauchi, Y., Hashimoto, N., Hattori, H., Ueda, M., Furukawa, K., Furukawa. K
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Journal Title
J.Biol.Chem.
Volume: 286
Issue: 21
Pages: 18526-37
DOI
Related Report
Peer Reviewed
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[Presentation] Regulatory mechanisms of malignant phenotypes of human cancers by tumor-associated carbohydrate antigens in the microdomains.2011
Author(s)
Koichi Furukawa, Kazunori Hamamura, Yuki Ohkawa, Noboru Hashimoto, Yuhsuke Ohmi,Yoshio Yamauchi, Keiko Furukawa:
Organizer
The 31st Naito Conference on Glycan Expression and Regulation[II]:Metabolites, Stress Response, Microdomains, and Beyond
Place of Presentation
Sapporo, Japan
Related Report
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