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Molecular mechanism of p38 alpha as a therapeutic target of metabolic syndrome

Research Project

Project/Area Number 23790362
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionMie University

Principal Investigator

OOKUMA Sadatsugu  三重大学, 大学院・医学系研究科, 助教 (70444429)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords代謝異常学 / メタボリックシンドローム / 炎症 / シグナル伝達 / マクロファージ / 生活習慣病
Research Abstract

In recent studies, it is revealed that chronic low-grade inflammation is involved in rising insulin resistance and metabolic syndrome. p38 is known as stress-activated protein kinase of mitogen-activated protein kinase (MAPK) family. To investigate the p38α functions in metabolic syndrome, we produced conditional knockout mice of p38α, in which p38α gene was disrupted in hematopoietic cells and vascular endotherial cells.In the p38α conditional knockout (cKO) mice, high fat diet-induced insulin resistance and obesity were significantly suppressed. High fat diet-induced infiltration of macrophage into adipose tissue was also suppressed in the p38α cKO mice. Expression level of genes regulating inflammation and chemotaxis was altered in the adipose tissue and ATM (adipose tissue macrophage) of the p38α cKO mice. These observations indicate that p38α is involved in the high fat diet-induced insulin resistance, probably through modifying macrophage infiltration. Furthermore, the expression of lipid metabolism genes was changed in liver of the p38α cKO mice. It suggests that p38αin blood cells regulates obesity via lipid metabolism in liver.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2013 2012 2011

All Presentation (15 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] p38α in blood cells regulates insulin resistance in mice2013

    • Author(s)
      大隈貞嗣
    • Organizer
      第10回プロテインホスファターゼ国際カンファレンス
    • Place of Presentation
      がん研究振興財団 国際研究交流会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] p38αMAP キナーゼは血球系を介してインスリン耐性を制御する2012

    • Author(s)
      大隈貞嗣 杉村和人 藤川隆彦 緒方正人
    • Organizer
      第5回 日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      東京大学
    • Year and Date
      2012-01-19
    • Related Report
      2012 Final Research Report
  • [Presentation] p38alpha regulates high-fat-induced chronic inflammation and hyperglycemia via blood cells2012

    • Author(s)
      S. Ookuma, T. Fujikawa, K. Sugimura, K.Otsu, M. Ogata
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] Roles of p38alpha mitogen-activated protein kinase in blood cells in high-fat-induced chronic inflammation and insulin resistance.2012

    • Author(s)
      S. Ookuma, K. Sugimura, M. Ogata
    • Organizer
      回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] p38α in blood cells regulates insulin resistance in mice2012

    • Author(s)
      S. Ookuma, T. Fujikawa, K. Sugimura, K Otsu, M. Ogata
    • Organizer
      プロテインホスファターゼ国際カンファレンス.
    • Place of Presentation
      がん研究振興財団 国際研究交流会館
    • Related Report
      2012 Final Research Report
  • [Presentation] p38alpha regulates high-fat-induced chronic inflammation and hyperglycemia via blood cells2012

    • Author(s)
      大隈貞嗣
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Roles of p38alpha mitogen-activated protein kinase in blood cells in high-fat-induced chronic inflammation and insulin resistance.2012

    • Author(s)
      大隈貞嗣
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] p38αMAPキナーゼは血球系を介してインスリン耐性を制御する2012

    • Author(s)
      大隈貞嗣
    • Organizer
      第5回 日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      大阪大学
    • Related Report
      2011 Research-status Report
  • [Presentation] Ogatap38alpha mitogen-activated protein kinase in blood cells is involved in insulin resistance2011

    • Author(s)
      S. Ookuma, K. Sugimura, M
    • Organizer
      第84回日本生化学会大会
    • Year and Date
      2011-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] メタボの新たな創薬ターゲットを提供するモデルマウス Model mice which provide novel medicinal targets for metabolic syndrome2011

    • Author(s)
      大隈貞嗣
    • Organizer
      東海国立3大学新技術説明会
    • Place of Presentation
      JSTホール
    • Year and Date
      2011-05-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 血球系におけるシグナル操作で肥満とメタボを防止する新規モデルマウス2011

    • Author(s)
      大隈貞嗣
    • Organizer
      第10回 国際 バイオ EXPO
    • Place of Presentation
      東京ビッグサイト
    • Year and Date
      2011-05-18
    • Related Report
      2012 Final Research Report
  • [Presentation] OgataContribution of p38α in blood cells to the regulation of obesity and blood glucose level2011

    • Author(s)
      S. Ookuma, K. Sugimura, M
    • Organizer
      第9回プロテインホスファターゼ国際カンファレンス
    • Related Report
      2012 Final Research Report
  • [Presentation] 血管血球系p38alphaはインスリン抵抗性と炎症性遺伝子発現を制御する2011

    • Author(s)
      S. Ookuma, K. Tauchi, T. Fujikawa, K.Sugimura, K. Otsu, M. Ogata
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉幕張メッセ
    • Related Report
      2012 Final Research Report
  • [Presentation] p38alpha mitogen-activated protein kinase in blood cells regulates insulin resistance and expression of inflammatory genes2011

    • Author(s)
      大隈貞嗣
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2011 Research-status Report
  • [Presentation] p38alpha mitogen-activated protein kinase in blood cells is involved in insulin resistance2011

    • Author(s)
      大隈貞嗣
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会館
    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 代謝活性化物質のスクリーニング方法、及び新規代謝活性化物質、代謝亢進モデルマウスの作製方法2011

    • Inventor(s)
      大隈貞嗣、藤川隆彦、緒方正人
    • Industrial Property Rights Holder
      三重大学
    • Industrial Property Number
      2008-289212
    • Filing Date
      2011
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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