Abnormality of the involvement of glycosylphosphatidylinositol anchor in a peroxisomal disorder.
Project/Area Number |
23790365
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | GPI アンカー / アルキルリン脂質 / ペルオキシソーム病 / 肢根型点状軟骨異形成症 / Zellweger 症候群 / GPIアンカー / RCDP / Zellweger症候群 / アルキルアシル型リン脂質 |
Research Abstract |
Dysfunction of peroxisome cause peroxisomal disorders. I analyzed the structure of glycosylphosphatidylinositol(GPI) anchor in patients of rhizomelic chondrodysplasia punctate(RCDP) and Zellweger syndrome. These patients are defective in alkyl-acyl form GPI anchor and expressing diacyl form GPI only. The expression levels of GPI-anchored protein increased in the mutant cells of responsible gene of RCDP. I found the involvements between peroxisomal disorders and functions of GPI-anchored protein.
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Report
(3 results)
Research Products
(7 results)