Mechanism of loss of function by nucleophosmin mutation in AML patients
Project/Area Number |
23790367
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
|
Research Institution | Shimane University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 分子病態学 / 病態医科学 / 細胞周期 / 国際研究者交流 |
Research Abstract |
Nucleolar protein nucleophosmin was associated with ribosomal protein RPL22 through its C-terminal region. This association was not direct but mediated by RNA. Both cellular localization nor association with RPL22 were influenced by phosphorylation on C-terminal region of nucleophosmin. However, mutant nucleophosmin found in AML patients, did not associate with RPL22.
|
Report
(3 results)
Research Products
(1 results)