Mechanism of loss of function by nucleophosmin mutation in AML patients

• Project/Area Number: 23790367
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Shimane University
• Principal Investigator: GYOSUKE Sakashita 島根大学, 医学部, 助教 (00397457)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 分子病態学 / 病態医科学 / 細胞周期 / 国際研究者交流

Research Abstract

Nucleolar protein nucleophosmin was associated with ribosomal protein RPL22 through its C-terminal region. This association was not direct but mediated by RNA. Both cellular localization nor association with RPL22 were influenced by phosphorylation on C-terminal region of nucleophosmin. However, mutant nucleophosmin found in AML patients, did not associate with RPL22.

Research Products

• [Remarks]
  • URL: http://www.med.shimane-u.ac.jp/biochem2/