| Project/Area Number |
23790369
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MATSUO Taisuke 徳島大学, 疾患プロテオゲノム研究センター, 特任助教 (70533222)
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| Research Collaborator |
KATAGIRI Toyomasa 徳島大学, 疾患プロテオゲノム研究センター, 教授 (60291895)
ONO Masaya 国立がんセンター研究所, 化学療法部, 室 長 (00270900)
MIYOSHI Yasuo 兵庫医科大学, 医学部, 教授 (50283784)
BANDO Yoshimi 徳島大学, 病院, 准教授 (00238239)
SASA Mitsunori とくしまブレストケアクリニック
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 糖転移酵素 / 乳癌 |
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| Research Abstract |
In this study, we report the critical role of a novel glycosyltransferase BCGT1 which was frequently up-regulated in breast cancers cells. Knockdown of BCGT1 expression by siRNA significantly suppressedbreast cancer cell growth. We detected the commonly down-regulation of the several endoplasmic reticulum (ER) chaperons, which is important for cell survival and growth of cancer cells, at protein and mRNA levels in BCGT1-depleted cells. These alterations werecaused through the glycosylation of ER stress sensor IRE1 protein by BCGT1.These results indicate that BCGT1 regulates cell growth through glycosylation of IRE1.
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