| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We demonstrated the importance of TFAM in functional regulation of human mitochondrial nucleoid and showed the machinery regulated by post-translational modification of TFAM. In addition, we observed the novel mechanism unique to mitochondrial acetylation. The mechanism in mitochondria was different from acetylation in nucleus and cytoplasm. By the mechanism, mitochondrial general protein were acetylated and were functionally regulated. Moreover, we identified that by the similar mechanism, mitochondrial protein were also succinylated and malonylated and were functionally regulated.
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