Human mitochondrial DNA nucleoid machinery regulated by TFAM
Project/Area Number |
23790370
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | Nagasaki International University (2014) Kyushu University (2011-2013) |
Principal Investigator |
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | ミトコンドリア / ヌクレオイド / 翻訳後修飾 / TFAM / ミトコンドリアDNA / 構造解析 |
Outline of Final Research Achievements |
We demonstrated the importance of TFAM in functional regulation of human mitochondrial nucleoid and showed the machinery regulated by post-translational modification of TFAM. In addition, we observed the novel mechanism unique to mitochondrial acetylation. The mechanism in mitochondria was different from acetylation in nucleus and cytoplasm. By the mechanism, mitochondrial general protein were acetylated and were functionally regulated. Moreover, we identified that by the similar mechanism, mitochondrial protein were also succinylated and malonylated and were functionally regulated.
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Report
(5 results)
Research Products
(8 results)
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[Journal Article] Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients.2012
Author(s)
Fang J, Uchiumi T, Yagi M, Matsumoto S, Amamoto R, Saito T, Takazaki S, Kanki T, Yamaza H, Nonaka K, Kang D.
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Journal Title
Biosci Rep
Volume: 32
Issue: 6
Pages: 631-639
DOI
Related Report
Peer Reviewed
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