NDRG2 deficient mice induces tumor formation and lifestyle related disease through the activation of AKT phosphorylation
Project/Area Number |
23790372
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
|
Research Institution | University of Miyazaki |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | がん / 成人病 / AKT / 癌 / シグナル伝達 / 国際情報交流 |
Research Abstract |
We reported that NDRG2 (N-myc downstream-regulated gene 2) is a candidate for tumor suppressor gene in ATLL(adult T-cell leukemia-lymphoma), which can modulate signal transduction of PI3K/AKT pathway. NDRG2 deficient mice developed various type of tumor with increased phosphorylated AKT in all organs. Furthermore, we indicated that NDRG2 deficient mice associated with lifestyle related disease such as brain disease, cardiac hypertrophy and fatty liver. These finding suggest thatNDRG2 may become a new therapeutic target for many type of disease
|
Report
(3 results)
Research Products
(22 results)
-
[Journal Article] Electrophilic Nitro-Fatty Acids Inhibit Vascular Inflammation by Disrupting LPS-Dependent TLR4 Signaling in Lipid Rafts2013
Author(s)
Villacorta L, Chang L, Salvatore SR, Ichikawa T, Zhang J, Petrovic-Djergovic D, Jia L, Carlsen H, Schopfer FJ, Freeman BA, Chen YE
-
Journal Title
Cardiovasc Res.
Volume: 98
Pages: 116-24
Related Report
-
-
[Journal Article] Overexpression of the DNA sensor protein, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation2012
Author(s)
Kondo Y, Nagai K, Nakahata S, Saito Y, Ichikawa T, Suekane A, Taki T, Iwakawa R, Enari M, Taniwaki M, Yokota J, Sakoda S, Morishita K
-
Journal Title
Cancer Sci
Volume: 103
Pages: 782-90
Related Report
-
[Journal Article] Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo2011
Author(s)
Tan Y, Ichikawa T(equal author), Li J, Si Q, Yang H, Chen X, Goldblatt CS, Meyer CJ, Li X, Cai L, Cui T
-
Journal Title
Diabetes
Volume: 60
Pages: 625-33
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-