Investigation of the mechanism underlying the effect of leptin on colorectal carcinogenesis
| Project/Area Number |
23790374
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
ENDO Hiroki 横浜市立大学, 附属病院, 助教 (70468164)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 大腸発がん / レプチン / 大腸発癌 |
|---|
| Research Abstract |
We clarified that leptin acts as a growth factor for colorectal cancer at stages subsequent to tumour initiation in colon carcinogenesis via leptin receptor/STAT3 pathway which was not activated in normal colonic epithelium and premalignant lesions because of lack of the leptin receptors, and then Wnt signalling contributes to the upregulation of leptin receptors in colonic epithelium.
|
Report
(3 results)
Research Products
(28 results)
-
-
-
-
-
-
[Journal Article] Identification of preneoplastic lesions as mucin-depleted foci in patients with sporadic colorectal cancer2012
Author(s)
Sakai E, Morioka T, Yamada E, Ohkubo H, Higurashi T, Hosono K, Endo H, Takahashi H, Takamatsu R, Cui C, Shiozawa M, Akaike M, Samura H, Nishimaki T, Nakajima A, Yoshimi N
-
Journal Title
Cancer Sci
Volume: 103(1)
Pages: 144-9
Related Report
Peer Reviewed
-
[Journal Article] Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression2011
Author(s)
Uchiyama T, Takahashi H, Endo H, Sugiyama M, Sakai E, Hosono K, Nagashima Y, Inayama Y, Wada K, Hippo Y, Nakajima A
-
Journal Title
Int J Oncol
Volume: 39(4)
Pages: 935-40
DOI
Related Report
Peer Reviewed
-
[Journal Article] Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis2011
Author(s)
Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H, Nakajima A
-
Journal Title
Gut
Volume: 60(10)
Issue: 10
Pages: 1363-71
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis.2011
Author(s)
Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H, Nakajima A.
-
Journal Title
Gut
Volume: 60
Pages: 1363-71
Related Report
Peer Reviewed
-
[Journal Article] Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression.2011
Author(s)
Uchiyama T, Takahashi H, Endo H, Sugiyama M, Sakai E, Hosono K, Nagashima Y, Inayama Y, Wada K, Hippo Y, Nakajima A.
-
Journal Title
Int J Oncol
Volume: 39
Pages: 935-40
Related Report
Peer Reviewed
-
-
-
-
-
[Presentation] The histopathological characteristics of mucin-depleted foci in patients with sporadic colorectal cancer2012
Author(s)
akai E, Takahashi H, Yamada E, Higurashi T, Ohkubo H, Hosono K, Endo H, Kato S, Nakajima A, Cui C, Takamatsu R, Yoshimi N
Organizer
AACR 2012 (pathogenesis of gastrointestinal and hepatocellular carcinomas)
Place of Presentation
Chicago, U.S.A
Year and Date
2012-04-02
Related Report
-
[Presentation] Validity of ACF using as a surrogate biomarker for colorectal cancer2011
Author(s)
Sakai E, Takahashi H, Kato S, Uchiyama T, Hosono K, Endo H, Maeda S, Yoneda M, Taguri M, Nakajima A
Organizer
AACR conference on frontiers in cancer prevention research, poster session
Place of Presentation
Boston, U.S.A.
Year and Date
2011-10-03
Related Report
-
-
-
-
-
-
-
-
-
-
-
