Investigation of the mechanism underlying the effect of leptin on colorectal carcinogenesis

• Project/Area Number: 23790374
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Yokohama City University
• Principal Investigator: ENDO Hiroki 横浜市立大学, 附属病院, 助教 (70468164)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 大腸発がん / レプチン / 大腸発癌

Research Abstract

We clarified that leptin acts as a growth factor for colorectal cancer at stages subsequent to tumour initiation in colon carcinogenesis via leptin receptor/STAT3 pathway which was not activated in normal colonic epithelium and premalignant lesions because of lack of the leptin receptors, and then Wnt signalling contributes to the upregulation of leptin receptors in colonic epithelium.

Research Products

• [Journal Article] Relationship of human rectal aberrant crypt foci and formation of colorectal polyp: One-year following up after polypectomy. (2012)
  • Author(s): Hirokazu Takahashi
  • Journal Title: World J Gastrointest Endosc Volume: 4 Issue: 12 Pages: 561-4
  • DOI: 10.4253/wjge.v4.i12.561
  • Peer Reviewed
• [Journal Article] Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas. (2012)
  • Author(s): Kunihiro Hosono
  • Journal Title: World J Gastroenterol. Volume: 18 Issue: 38 Pages: 5360-8
  • DOI: 10.3748/wjg.v18.i38.5360
  • Peer Reviewed
• [Journal Article] Eicosapentaenoic acid (EPA) efficacy for colorectal aberrant crypt foci (ACF): a double-blind randomized controlled trial. (2012)
  • Author(s): Takuma Higurashi
  • Journal Title: BMC Cancer Volume: 12 Issue: 1 Pages: 413-413
  • DOI: 10.1186/1471-2407-12-413
  • Peer Reviewed
• [Journal Article] Number of aberrant crypt foci in the rectum is a useful surrogate marker of colorectal adenoma recurrence. (2012)
  • Author(s): Takashi Uchiyama
  • Journal Title: Dig Endosc Volume: 24 Issue: 5 Pages: 353-7
  • DOI: 10.1111/j.1443-1661.2012.01289.x
  • Peer Reviewed
• [Journal Article] Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial. (2012)
  • Author(s): Higurashi T, Takahashi H, Endo H, Hosono K, Uchiyama T, Hata Y,Ezuka A, Yamanaka S, Inayama Y,et.al.
  • Journal Title: BMC Cancer. Volume: 12(1) Issue: 1 Pages: 118-118
  • DOI: 10.1186/1471-2407-12-118
  • Peer Reviewed
• [Journal Article] Identification of preneoplastic lesions as mucin-depleted foci in patients with sporadic colorectal cancer (2012)
  • Author(s): Sakai E, Morioka T, Yamada E, Ohkubo H, Higurashi T, Hosono K, Endo H, Takahashi H, Takamatsu R, Cui C, Shiozawa M, Akaike M, Samura H, Nishimaki T, Nakajima A, Yoshimi N
  • Journal Title: Cancer Sci Volume: 103(1) Pages: 144-9
  • Peer Reviewed
• [Journal Article] Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression (2011)
  • Author(s): Uchiyama T, Takahashi H, Endo H, Sugiyama M, Sakai E, Hosono K, Nagashima Y, Inayama Y, Wada K, Hippo Y, Nakajima A
  • Journal Title: Int J Oncol Volume: 39(4) Pages: 935-40
  • DOI: 10.3892/ijo.2011.1105
  • Peer Reviewed
• [Journal Article] Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis (2011)
  • Author(s): Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H, Nakajima A
  • Journal Title: Gut Volume: 60(10) Issue: 10 Pages: 1363-71
  • DOI: 10.1136/gut.2010.235754
  • Peer Reviewed
• [Journal Article] 【消化器癌をめぐる栄養療法】 食事摂取により増大する大腸癌:レプチンシグナルの関与 (2011)
  • Author(s): 遠藤宏樹、細野邦広、酒井英嗣、内山崇、日暮琢磨、高橋宏和、中島淳
  • Journal Title: 消化器内科(1844-2895) Volume: 52巻6号 Pages: 582-590
  • URL: http://ci.nii.ac.jp/naid/40018927290
• [Journal Article] Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis. (2011)
  • Author(s): Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H, Nakajima A.
  • Journal Title: Gut Volume: 60 Pages: 1363-71
  • Peer Reviewed
• [Journal Article] Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression. (2011)
  • Author(s): Uchiyama T, Takahashi H, Endo H, Sugiyama M, Sakai E, Hosono K, Nagashima Y, Inayama Y, Wada K, Hippo Y, Nakajima A.
  • Journal Title: Int J Oncol Volume: 39 Pages: 935-40
  • Peer Reviewed
• [Journal Article] 食事摂取により増大する大腸癌：レプチンシグナルの関与. (2011)
  • Author(s): 遠藤宏樹、細野邦広、酒井英嗣、内山崇、日暮琢磨、高橋宏和、中島淳.
  • Journal Title: 消化器内科 Volume: 52 Pages: 582-590
• [Presentation] 大腸腫瘍を増大させるレプチンシグナル: Cre/flox動物モデルを用いた検討 (2012)
  • Author(s): 日暮琢磨, 遠藤宏樹, 酒井英嗣, 大久保秀則, 山田英司, 高橋宏和, 中島淳
  • Organizer: 第71回日本癌学会学術総会 ポスターセッション (化学物質とがん予防)
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-20
• [Presentation] 低用量 resveratrol は大腸腫瘍の initiationに影響を与えないが, STAT3 経路を介して大腸腫瘍の progression を抑制する (2012)
  • Author(s): 酒井英嗣, 遠藤宏樹, 中島淳, 山田英司, 日暮琢磨, 大久保秀則, 高橋宏和
  • Organizer: 第71回日本癌学会学術総会 口演 (化学物質とがん予防)
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-20
• [Presentation] レスベラトロールによる大腸発癌予防効果に関する検討 (2012)
  • Author(s): 酒井英嗣, 遠藤宏樹, 中島淳
  • Organizer: 第98回日本消化器病学会総会 ミニシンポジウム 2 (Nutraceutical をめぐって)
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2012-04-19
• [Presentation] The histopathological characteristics of mucin-depleted foci in patients with sporadic colorectal cancer (2012)
  • Author(s): akai E, Takahashi H, Yamada E, Higurashi T, Ohkubo H, Hosono K, Endo H, Kato S, Nakajima A, Cui C, Takamatsu R, Yoshimi N
  • Organizer: AACR 2012 (pathogenesis of gastrointestinal and hepatocellular carcinomas)
  • Place of Presentation: Chicago, U.S.A
  • Year and Date: 2012-04-02
• [Presentation] Validity of ACF using as a surrogate biomarker for colorectal cancer (2011)
  • Author(s): Sakai E, Takahashi H, Kato S, Uchiyama T, Hosono K, Endo H, Maeda S, Yoneda M, Taguri M, Nakajima A
  • Organizer: AACR conference on frontiers in cancer prevention research, poster session
  • Place of Presentation: Boston, U.S.A.
  • Year and Date: 2011-10-03
• [Presentation] 肥満と大腸癌: メカニズムと予防 (2011)
  • Author(s): 中島淳、遠藤宏樹、酒井英嗣、高橋宏和
  • Organizer: 第28回日本医学会総会2011東京,シンポジウム6 (からだの調節と代謝, 肥満の成因と治療)
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-04-08
• [Presentation] 肥満と大腸癌: 大腸腫瘍を増大させるレプチンシグナル (2011)
  • Author(s): 遠藤宏樹、内山崇、酒井英嗣、細野邦広、高橋宏和、中島淳
  • Organizer: 第7回日本消化管学会総会学術集会 ワークショップ16 (肥満, 代謝異常と消化管疾患: 病態解明への新たなアプローチ)
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2011-02-02
• [Presentation] 大腸発癌におけるIL-6の作用解析 (2011)
  • Author(s): 内山崇、高橋宏和、酒井英嗣、杉山美智子、細野邦広、遠藤宏樹、中島淳
  • Organizer: 第7回日本消化管学会総会学術集会 ワークショップ16 (肥満, 代謝異常と消化管疾患:病態解明への新たなアプローチ)
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2011-02-02
• [Presentation] 新規大腸化学発癌予防薬としてのResveratrolの可能性 (2011)
  • Author(s): 酒井英嗣、遠藤宏樹、中島淳
  • Organizer: 第7回日本消化管学会総会学術集会 ワークショップ7 (大腸癌の治療, 予防に向けた新規標的分子の探索)
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2011-02-02
• [Presentation] The histopathological characteristics of mucin-depleted foci in patients with sporadic colorectal cancer.
  • Author(s): Eiji Sakai、Hiroki Endo
  • Organizer: AACR Annual Meeting 2012:
  • Place of Presentation: U.S.A., Chicago
• [Presentation] 大腸腫瘍を増大させるレプチンシグナル: 動物モデルを用いた検討.
  • Author(s): 日暮琢磨、遠藤宏樹
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京）
• [Presentation] レスベラトロールによる大腸発癌予防効果に関する検討.
  • Author(s): 酒井英嗣、遠藤宏樹
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京）
• [Presentation] 低用量resveratrolは大腸腫瘍のinitiationに影響を与えないが, STAT3経路を介して大腸腫瘍のprogressionを抑制する.
  • Author(s): 酒井英嗣、遠藤宏樹
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（札幌）
• [Presentation] 大腸腫瘍を増大させるレプチンシグナル: Cre/flox動物モデルを用いた検討.
  • Author(s): 日暮琢磨、遠藤宏樹
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（札幌）
• [Remarks] 横浜市立大学附属病院 分子消化管内科学
  • URL: http://www-user.yokohama-cu.ac.jp/~nai3syou/member.html
• [Remarks] 横浜市立大学附属病院 分子消化管内科学
  • URL: http://www-user.yokohama-cu.ac.jp/~nai3syou/member.html