Analysis of CD44 role in metabolism of leukemic stem cell
Project/Area Number |
23790376
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | Keio University |
Principal Investigator |
SUGIHARA Eiji 慶應義塾大学, 医学部, 特任助教 (50464996)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 白血病幹細胞 / CD44 / 酸化ストレス / 白血病 / 癌 / 代謝 / 癌幹細胞 / シグナル伝達 |
Research Abstract |
Leukemic stem cells (LSCs) have been reported to be implicated in the maintenance of overall tumor and tumor recurrence. However the mechanisms of these events are largely unknown. In this study, we established B-ALL and CML mice models derived from bone
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Arf/p53 module, which induces apoptosis, downregulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.2013
Author(s)
Atsumi Y, Inase A, Osawa T, Sugihara E, Sakasai R, Fujimori H, Teraoka H, Saya H, Kanno M, Tashiro F, Nakagama H, Masutani M, Yoshioka KI
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Journal Title
J Biol Chem
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Twist2 functions as a tumor suppressor in murine osteosarcoma cells.2013
Author(s)
Ishikawa T, Shimizu T, Ueki A, Yamaguchi S, Onishi N, Sugihara E, Kuninaka S, Miyamoto T, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Mabuchi Y, Matsuzaki Y, Yamaguchi R, Miyano S and Saya H
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Journal Title
Cancer Sci
Volume: (in press)
Issue: 7
Pages: 880-888
DOI
Related Report
Peer Reviewed
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[Journal Article] xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma2013
Author(s)
Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O
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Journal Title
Cancer Res
Volume: 73(6)
Issue: 6
Pages: 1855-1866
DOI
Related Report
Peer Reviewed
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[Journal Article] Up-regulation of imp3 confers in vivo tumorigenicity on murine osteosarcoma cells.2012
Author(s)
Ueki A, Shimizu T, Masuda K, Yamaguchi SI, Ishikawa T, Sugihara E, Onishi N, Kuninaka S, Miyoshi K, Muto A, Toyama Y, Banno K, Aoki D, Saya H.
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Journal Title
PLoS One
Volume: 7(11)
Issue: 11
Pages: e50621-e50621
DOI
Related Report
Peer Reviewed
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[Journal Article] Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma.2012
Author(s)
Shimizu T, Ishikawa T, Iwai S, Ueki A, Sugihara E, Onishi N, Kuninaka S, Miyamoto T, Toyama Y, Ijiri H, Mori H, Matsuzaki Y, Yaguchi T, Nishio H, Kawakami Y, Ikeda Y and Saya H
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Journal Title
Mol Cancer Res
Volume: 10(3)
Pages: 454-468
Related Report
Peer Reviewed
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[Journal Article] Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells.2012
Author(s)
Tamada M, Nagano O, Tateyama S, Ohmura M, Yae T, Ishimoto T, Sugihara E, Onishi N, Yamamoto T, Yanagawa H, Suematsu M and Saya H
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Journal Title
Cancer Res
Volume: 72(6)
Pages: 1438-1448
Related Report
Peer Reviewed
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[Journal Article] Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells2011
Author(s)
Sampetrean O, Saga I, Nakanishi M, Sugihara E, Fukaya R, Onishi N, Osuka A, Akahata M, Kai K, Sugimoto H, Hirao A, and Saya H
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Journal Title
Neoplasia
Volume: 13(9)
Pages: 784-791
Related Report
Peer Reviewed
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[Journal Article] Establishment of a Choriocarcinoma Model from Immortalized Normal Extravillous Trophoblast Cells Transduced with HRASV122011
Author(s)
Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, Onishi N, Sugihara E, Nagano O, Banno K, Kuninaka S, Aoki D, Saya H
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Journal Title
Am J Pathol.
Volume: 179(3)
Issue: 3
Pages: 1471-82
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment of a Choriocarcinoma Model from Immortalized Normal Extravillous Trophoblast Cells Transduced with HRASV122011
Author(s)
Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, Onishi N, Sugihara E, Nagano O, Banno K, Kuninaka S, Aoki D, Saya H
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Journal Title
Am J Pathol
Volume: 179(3)
Pages: 1471-1482
Related Report
Peer Reviewed
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[Journal Article] Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells.2011
Author(s)
Sampetrean O, Saga I, Nakanishi M, Sugihara E, Fukaya R, Onishi N, Osuka A, Akahata M, Kai K, Sugimoto H, Hirao A, and Saya H
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Journal Title
Neoplasia
Volume: 13(9)
Pages: 784-791
Related Report
Peer Reviewed
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