Analysis of the molecular mechanism of disease based on the functional aberration of aPKC-PAR complex
Project/Area Number |
23790379
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | Tottori University (2012-2013) Tokai University (2011) |
Principal Investigator |
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 細胞極性 / aPKC-PAR / アピカル膜ドメイン / 酸化ストレス / 管腔構造 / アピカルドメイン |
Research Abstract |
Excessive productions of free radicals and oxidative stress are implicated in the pathogenesis of cancer, cirrhosis and inflammatory bowel diseases. However, the effect of oxidative stress on cell polarity or tissue morphology is still unknown. Here we demonstrated that carbon tetrachloride (CCl4)-induced oxidative stress resulted in the loss of cell polarity in rat liver. Furthermore, the polarity regulating protein complex, aPKC-PAR complex (Par-3-aPKC-Par-6 ternary complex) formation was inhibited by aberrant activation of aPKC through CCl4 treatment. Our findings would contribute to understanding of molecular basis of oxidative stress-induced disease and to the innovation of diagnostic techniques.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Localization of aPKC lambda/iota and its interacting protein, Lgl2, is significantly associated with lung adenocarcinoma progression2013
Author(s)
Imamura N, Horikoshi Y, Matsuzaki T, Toriumi K, Kitatani K, Ogura G, Masuda R, Nakamura N, Takekoshi S, Iwazaki M
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Journal Title
Tokai J Exp Clin Med
Volume: 38(4)
Pages: 146-158
Related Report
Peer Reviewed
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[Journal Article] Localization of aPKC lambda/iota and its interacting protein, Lgl2, is significantly associated with lung adenocarcinoma progression2013
Author(s)
Imamura N, Horikoshi Y, Matsuzaki T, Toriumi K, Kitatani K, Ogura G, Masuda R, Nakamura N, Takekoshi S, Iwazaki M
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Journal Title
The Tokai journal of experimental and clinical medicine
Volume: 38
Pages: 146-159
Related Report
Peer Reviewed
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[Presentation] 神話「因幡の白兎」とビタミンE2014
Author(s)
大塚裕眞,妻鹿倫征,森川さくら,平井真理子,大津匡弘,羽賀大貴,堀越洋輔,中曽一裕,松浦達也
Organizer
第25回ビタミンE研究会
Place of Presentation
米子
Year and Date
2014-01-25
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