| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Excessive productions of free radicals and oxidative stress are implicated in the pathogenesis of cancer, cirrhosis and inflammatory bowel diseases. However, the effect of oxidative stress on cell polarity or tissue morphology is still unknown.
Here we demonstrated that carbon tetrachloride (CCl4)-induced oxidative stress resulted in the loss of cell polarity in rat liver. Furthermore, the polarity regulating protein complex, aPKC-PAR complex (Par-3-aPKC-Par-6 ternary complex) formation was inhibited by aberrant activation of aPKC through CCl4 treatment. Our findings would contribute to understanding of molecular basis of oxidative stress-induced disease and to the innovation of diagnostic techniques.
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