Interaction between pathogens and host genes undergoing natural selection

• Project/Area Number: 23790385
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human genetics
• Research Institution: Osaka University
• Principal Investigator: HIRAYASU Kouyuki 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (30585170)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 自然選択 / 感染症 / 活性化型レセプター / 遺伝子多型 / 細菌

Research Abstract

Infectious diseases are still threats to humans, and the mechanism by which pathogens infect their hosts is not fully understood yet. The present study tested the hypothesis that molecules carrying mutations with unknown function interact with pathogens. In the process of comprehensive search for interaction between pathogens and host molecules, it was found that an orphan activating receptor specifically recognized some host molecule degraded by bacteria. These results suggest that host immune system has a novel strategy to sense bacterial invasion via an activating receptor.

Research Products

• [Journal Article] A motif in LILRB2 eritieal for Angptl2 binding and aetivation (2014)
  • Author(s): Deng, M., Lu, Z., Zheng, ]., Wan, X., Chen, X., Hirayasu, K., Sun, H., Lam, Y., Chen, L., Wang, Q., Song, C., Huang, N., Gao, F. G., Jiang, Y., Arase, H., and Zhang, C.
  • Journal Title: Blood Volume: (in press)
  • Peer Reviewed
• [Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility (2014)
  • Author(s): Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H
  • Journal Title: Proceedings of National Academy of Science USA Volume: 111 Issue: 10 Pages: 3787-3792
  • DOI: 10.1073/pnas.1401105111
  • Peer Reviewed / Open Access
• [Journal Article] Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules. (2013)
  • Author(s): Jiang, Y., Arase, N., Kohyama, M., Hirayasu, K., Suenaga, T., Jin, H., Matsumoto, M., Shida, K., L. Lanier, L., Saito, T. and Arase, H.
  • Journal Title: Int. Immunol. Volume: 25 Issue: 4 Pages: 235-246
  • DOI: 10.1093/intimm/dxs155
  • Peer Reviewed
• [Journal Article] Significant Association of KIR2DL3-HLA-C1 Combination with Cerebral Malaria and Implications for Co-evolution of KIR and HLA. (2012)
  • Author(s): Hirayasu, K., Ohashi, J., Kashiwase, K., Hananantachai, H., Naka, I., Ogawa, A., Takanashi, M., Satake, M., Nakajima, K., Parham, P., Arase, H., Tokunaga, K., Patarapotikul, J., Yabe, T.
  • Journal Title: PLoS Pathog. Volume: 8 Issue: 3 Pages: e1002565-e1002565
  • DOI: 10.1371/journal.ppat.1002565
  • Peer Reviewed
• [Presentation] Rheumatoid faetor binding to IgG heavy ehain presented on HLA DR is assoeiated with Rheumatoid Arthritis suseeptibility (2013)
  • Author(s): Jin Hui, Arase Noriko, Kohayama Masako, Saito Fumiji, Hirayasu Kouyuki, Matsumoto Maki, Shida Kyoko, Suenaga Tadahiro, Saito Takashi, Katayama Iehiro, Lanier Lewis L., Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2013-12-13
• [Presentation] 2 glyeoprotein I presented on MHC elass II moleeules are reeognized by autoantibodies in antiphospholipid syndrome (2013)
  • Author(s): Tanimura Kenji, Suenaga Tadahiro, ]in Hui, Hirayasu Kouyuki, Arase Noriko, Kohayama Masako, Ebina Yasuhiko, Yasuda Shinsuke, Horita Tetsuya, Katayama Iehiro, Atsumi Tatsuya, Yamada Hideo, Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2013-12-13
• [Presentation] Immune sensing system for immunoglobulin degradation by baeteria (2013)
  • Author(s): Hirayasu Kouyuki, Saito Fumiji, Horiguehi Yasuhiko, Nagai Hiroki, Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2013-12-11
• [Presentation] Transport of misfolded ER proteins to the eell surfaee by MHC elass II moleeules (2012)
  • Author(s): Yan Jiang, Hui Jin, Masako Kohyama, Noriko Arase, Kouyuki Hirayasu, Tadahiro Suenaga, Maki Matsumoto, Kyoko Shida, Lewis L. Lanier, Takashi Saito, Iehiro Katayama and Hisashi Arase
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2012-12-06
• [Presentation] Signifieant assoeiation of KIR2DL3 HLA C1 eombination with eerebral malaria and implieations for eo evolution of KIR and HLA (2012)
  • Author(s): Kouyuki Hirayasu
  • Organizer: Franee ]apan International Exehange Symposium
  • Place of Presentation: 大阪大学(大阪)
  • Year and Date: 2012-02-10
• [Presentation] Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA (2012)
  • Author(s): Kouyuki Hirayasu
  • Organizer: France-Japan International Exchange Symposium
  • Place of Presentation: 大阪大学（大阪府）
• [Presentation] Rheumatoid factor binding to IgG heavy chain presented on HLA-DR is associated with Rheumatoid Arthritis susceptibility
  • Author(s): Jin Hui, Arase Noriko, Kohayama Masako, Saito Fumiji, Hirayasu Kouyuki, Matsumoto Maki, Shida Kyoko, Suenaga Tadahiro, Saito Takashi, Katayama Ichiro, Lanier Lewis L., Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉市）
• [Presentation] β2-glycoprotein I presented on MHC class II molecules are recognized by autoantibodies in antiphospholipid syndrome
  • Author(s): Tanimura Kenji, Suenaga Tadahiro, Jin Hui, Hirayasu Kouyuki, Arase Noriko, Kohayama Masako, Ebina Yasuhiko, Yasuda Shinsuke, Horita Tetsuya, Katayama Ichiro, Atsumi Tatsuya, Yamada Hideo, Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉市）
• [Presentation] PILRα negatively regulates DSS induced experimental colitis
  • Author(s): Kishida Kazuki, Kohyama Masako, Kurashima Yosuke, Wang Jing, Hirayasu Kouyuki, Suenaga Tadahiro, Kiyono Hiroshi, Kunisawa Jun, Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉市）
• [Presentation] Immune sensing system for immunoglobulin degradation by bacteria
  • Author(s): Hirayasu Kouyuki, Saito Fumiji, Horiguchi Yasuhiko, Nagai Hiroki, Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉市）
• [Presentation] Transport of misfolded ER proteins to the cell surface by MHC class II molecules
  • Author(s): Jiang, Y., Arase, N., Kohyama, M., Hirayasu, K., Suenaga, T., Jin, H., Matsumoto, M., Shida, K., L. Lanier, L., Saito, T. and Arase, H.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Book] 週刊医学のあゆみ「免疫グロプリン様受容体による免疫制御と疾患」 (2013)
  • Author(s): 平安恒幸
  • Publisher: 医歯薬出版株式会社
• [Book] 医学のあゆみ「免疫グロブリン様受容体による免疫制御と疾患」 (2013)
  • Author(s): 平安 恒幸
  • Publisher: 医歯薬出版株式会社
• [Remarks]
  • URL: http://immehem.biken.osakau.ae.jp/index.html
• [Remarks] 免疫化学研究室ホームページ
  • URL: http://immchem.biken.osaka-u.ac.jp/
• [Remarks] 大阪大学免疫学フロンティア研究センター免疫化学研究室
  • URL: http://immchem.biken.osaka-u.ac.jp/
• [Remarks]
  • URL: http://immchem.biken.osaka-u.ac.jp/publication.html