| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We examined the relationships between regulation mechanisms of gonadal sex differentiation and disorders of sex development (DSD). In the DSD line mice (Ypos), inappropriate spatiotemporal expression of sex differentiation related factors in the developing gonad cause different phenotype from the same genetic background. In the Turner mosaic patient, the expression of sex differentiation related genes differed by gonads on both side, and the mRNA expression level was not consisting with mosaic ratio or protein expression. In addition, both three-dimensional structure and cell adherence were indispensable for the maintenance of the Sertoli cell characteristics under the culture condition. Furthermore, it became clear that GATA4 regulates expression of DMRT1 in the developing chicken gonads, and DMRT1 has various roles in the chicken embryo.
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