Clinicopathologic features of gastric cancer associated with liver metastasis

• Project/Area Number: 23790390
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: The University of Tokyo
• Principal Investigator: USHIKU Tetsuo 東京大学, 医学部附属病院, 助教 (60376415)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 胃癌 / 肝転移

Research Abstract

This project demonstrated that embryonic stem cell markers, such as SALL4 and Claudin-6, were specifically expressed in a subset of gastric cancer which is highly associated with liver metastasis. This subset of gastric cancer showed relatively high frequency of HER2 positivity as well. Finally, we clarified the clinicopathologic features of very well differentiated gastric carcinoma with intestinal type, which is unlikely to develop metastatic disease.

Research Products

• [Journal Article] Very well-differentiated gastric carcinoma of intestinal type analysis of diagnostic criteria (2013)
  • Author(s): Ushiku T, Arnason T, Ban S, Hishima T, Shimizu M, Fukayama M, Lauwers GY.
  • Journal Title: Modern Pathology.
  • Peer Reviewed
• [Journal Article] Distinct expression pattern of claudin-6, a primitive phenotypic tight junction molecule, in germ cell tumours and visceral carcinomas. (2012)
  • Author(s): Ushiku T, Shinozaki-Ushiku A, Maeda D, Morita S, Fukayama M.
  • Journal Title: Histopathology. Volume: 61(6) Issue: 6 Pages: 1043-56
  • DOI: 10.1111/j.1365-2559.2012.04314.x
  • Peer Reviewed
• [Journal Article] ARID1A expression loss in gastric cancer: Pathway-dependent roles with and without Epstein-Barr virus infection and microsatellite instability (2012)
  • Author(s): Abe H, Maeda D, Hino R, Otake Y, Isogai M, Ushiku AS, Matsusaka K,Kunita A, Ushiku T, Uozaki H,Tateishi Y, Hishima T, Iwasaki Y, Ishikawa S, Fukayama M
  • Journal Title: Virchows Archiv Volume: 461 Issue: 4 Pages: 367
  • DOI: 10.1007/s00428-012-1303-2
  • Peer Reviewed
• [Journal Article] SOX9 expression and its methylation status in gastric cancer (2012)
  • Author(s): Sun M, Uozaki H, Hino R, Kunita A, Shinozaki A, Ushiku T, Hibiya T,Takeshita K, Isogai M, Takada K,Fukayama M
  • Journal Title: Virchows Archiv Volume: 460 Issue: 3 Pages: 271
  • DOI: 10.1007/s00428-012-1201-7
  • Peer Reviewed
• [Journal Article] Gastric carcinoma with invasive micropapillary pattern and its association with node metastasis. (2011)
  • Author(s): Ushiku T, Matsusaka K, Iwasaki Y,Tateishi Y, Funata N, Seto Y,Fukayama M.
  • Journal Title: Histopathology. Volume: 59(6) Issue: 6 Pages: 1081-89
  • DOI: 10.1111/j.1365-2559.2011.04055.x
  • Peer Reviewed
• [Journal Article] Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes (2011)
  • Author(s): Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, Uozaki H, Seto Y,Takada K, Aburatani H, Fukayama M
  • Journal Title: Cancer Res Volume: 71 Issue: 23 Pages: 7187
  • DOI: 10.1158/0008-5472.can-11-1349
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus-associated gastric carcinoma.Pathology (2011)
  • Author(s): Fukayama M, Ushiku T
  • Journal Title: Research and Practice Volume: Vol.207 Issue: 9 Pages: 529-53
  • DOI: 10.1016/j.prp.2011.07.004
  • Peer Reviewed
• [Journal Article] 専門医のためのアトラス EBV関連胃癌 (2011)
  • Author(s): 牛久哲男、深山正久
  • Journal Title: 胃癌perspective Volume: 4(4) Pages: 260-264
• [Presentation] Very well differentiated gastric cancer of intestinal metaplasia-type: a systemic analysis (2013)
  • Author(s): Ushiku T.
  • Organizer: The United States & Canadian Academy of Pathology's 102nd Annual Meeting.
  • Place of Presentation: Baltimore, USA.
  • Year and Date: 2013-03-05
• [Presentation] Focally enhanced gastritis in pediatric inflammatory bowel disease: patterns,associations and significance (2013)
  • Author(s): Ushiku T.
  • Organizer: The United States & Canadian Academy of Pathology's 102 Annual Meeting.
  • Place of Presentation: Baltimore, USA.
  • Year and Date: 2013-03-04
• [Presentation] Very Well Differentiated Gastric Cancer of Intestinal Metaplasia-Type: A Systemic Analysis (2013)
  • Author(s): Tetsuo Ushiku
  • Organizer: The United States & Canadian Academy of Pathology’s 102nd Annual Meeting
  • Place of Presentation: Boltimore, USA
• [Presentation] EBV陽性胃癌におけるDNAメチル化の網羅的解析 (2012)
  • Author(s): 松坂恵介
  • Organizer: 第9回EBウイルス研究会
  • Place of Presentation: 米子
  • Year and Date: 2012-07-06
• [Presentation] 新規手法を用いた胃癌におけ る HER2 遺伝子増幅の検討 (2012)
  • Author(s): 松坂恵介
  • Organizer: 日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
• [Presentation] 胃癌リンパ節転移巣におけるHER2 発現不均一性の検討 (2012)
  • Author(s): 金子伸行
  • Organizer: 日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
• [Presentation] Epstein-Barr virus関連胃癌及び非関連胃癌におけるARID1A発現消失の臨床病理学的検討 (2012)
  • Author(s): 阿部浩幸
  • Organizer: 日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
• [Presentation] Epstein-Barr virus関連胃癌及び非関連胃癌におけるARID1A発現消失の臨床病理学的検討
  • Author(s): 阿部浩幸
• [Presentation] 新規手法を用いた胃癌におけるHER2遺伝子増幅の検討
  • Author(s): 松坂恵介
  • Organizer: 日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 胃癌リンパ節転移巣におけるHER2発現不均一性の検討
  • Author(s): 金子伸行
  • Organizer: 日本病理学会総会
  • Place of Presentation: 東京
• [Remarks] 東京大学医学系研究科人体病理学・病理診断学ホームページ
  • URL: http://pathol.umin.ac.jp/index.shtml
• [Remarks] 東京大学人体病理・病理診断学分野ホームページ
  • URL: http://pathol.umin.ac.jp/index.shtml