Analysis of cell adhesion molecule 1 (CADM1)-mediated inactivation of c-Src pathway

• Project/Area Number: 23790391
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: The University of Tokyo
• Principal Investigator: TSUBOI Yumi 東京大学, 医科学研究所, 特任研究員 (80584226)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 分子病理 / 大腸癌 / CADM1

Research Abstract

To investigate additional functions of CADM1 in the epithelial cell membrane, we adopted a proteomic approach and identified Csk-binding protein (Cbp), which suppress c-Src mediated transformation and tumorigenesis. We found that CADM1 formed a protein complex with Cbp and c-Src in lipid raft fractions, and suggested to promote c-Src inactivation in a Cbp-dependent manner.

Research Products

• [Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer. (2012)
  • Author(s): Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Maruyama T, Tsuda H, Kanai Y, Onizuka M, Sato Y, Murakami Y.
  • Journal Title: Cancer Sci. Volume: 103(6) Pages: 1051-1057
• [Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer (2012)
  • Author(s): Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Maruyama T, Tsuda H, Kanai Y, 0nizuka M, Sato Y, Murakami Y
  • Journal Title: Cancer Science Volume: 103 Issue: 6 Pages: 1051-1057
  • DOI: 10.1111/j.1349-7006.2012.02277.x
  • Peer Reviewed
• [Journal Article] Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells. (2011)
  • Author(s): Ito T, Williams-Nate Y, Iwai M, Tsuboi Y, Hagiyama M, Ito A, Sakurai-Yageta M,Murakami Y.
  • Journal Title: Genes Cells Volume: 16(7) Pages: 791-802
• [Journal Article] Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells (2011)
  • Author(s): Ito T, Williams-Nate Y, Iwai M, Tsuboi Y, Hagiyama M, Ito A, Sakurai-Yageta M, Murakami Y
  • Journal Title: Genes to Cells Volume: 16 Issue: 7 Pages: 791-802
  • DOI: 10.1111/j.1365-2443.2011.01525.x
  • Peer Reviewed
• [Presentation] Analysis of cell adhesion molecule 1 (CADM1)-mediated inactivation of c-Src pathway (2013)
  • Author(s): Tsuboi Y, Oyama M, Kozuka-Hata H, Ito A, Murakami Y.
  • Organizer: 19th International Charles Heidelberger Symposium on Cancer Research
  • Place of Presentation: 鹿児島市
• [Presentation] Roles of a cell adhesion molecule CADM1 in malignant progression of non-small celllung cancer (2013)
  • Author(s): Ito T, Kuwano H, Sakurai-Yageta M, Tsuboi Y, Matsubara D, Murakami Y.
  • Organizer: 19th International Charles Heidelberger Symposium on Cancer Research (
  • Place of Presentation: 鹿児島市
• [Presentation] Analysis of cell adhesion molecule 1 (CADM1)-mediated inactivation of c-Src pathway. (2013)
  • Author(s): Tsuboi Y
  • Organizer: 19th International Charles Heidelberger Symposium on Cancer Research
  • Place of Presentation: 鹿児島
• [Presentation] Analysis of cell adhesion molecule 1 (CADM1)-mediated inactivation of c-Src pathway (2012)
  • Author(s): Tsuboi Y, Oyama M, Kozuka-Hata H, Ito A, Murakami Y.
  • Organizer: The 35th Annual Meetingof the Molecular Biology Society of Japan
  • Place of Presentation: 福岡市
• [Presentation] Analysis of a mechanism to stabilize tumor suppressor protein CADM1 (2012)
  • Author(s): Nakaoka H, Tsuboi Y, Sakurai-Yageta M, Maruyama T, Matsubara D, Murakami Y.
  • Organizer: The 35th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: 福岡市
• [Presentation] Analysis of cell adhesion molecule 1 (CADM1)-mediated inactivation of c-Src pathway. (2012)
  • Author(s): Tsuboi Y
  • Organizer: 6th Retreat Meeting of the IMSUT & RCAST Global COE in OIST
  • Place of Presentation: 沖縄
• [Presentation] Analysis of cell adhesion molecule 1 (CADM1)-mediated inactivation of c-Src pathway. (2012)
  • Author(s): Tsuboi Y
  • Organizer: The 35th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: 福岡
• [Presentation] Dual roles of a cell adhesion molecule,CADM1/TSLC1, in oncogenesis (2011)
  • Author(s): Murakami Y, Nagata M, Sakurai-Yageta M,Kawai T, Tsuboi Y, Iwai M, Masuda M, GotoA.
  • Organizer: The 3 CREST〓SBM International Conference:Mathematical Methods in Cancer CellBiology
  • Place of Presentation: 広島市
• [Presentation] Analysis of cell adhesionmolecule 1 (CADM1)-mediated inactivation of c-Src pathway (2011)
  • Author(s): Tsuboi Y, Oyama M, Kozuka-Hata H, Ito A, Murakami Y.
  • Organizer: The 34th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: 横浜市
• [Presentation] Analysis of cell adhesion molecule 1 (CADM1)-mediated inactivation of c-Src pathway. (2011)
  • Author(s): Tsuboi Y, Oyama M, Kozuka-Hata H, Ito A, Murakami Y.
  • Organizer: The 34th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: 横浜