| Project/Area Number |
23790393
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Research Collaborator |
NAIKI Hironobu 福井大学, 医学部, 教授 (10227704)
HASEGAWA Kazuhiro 福井大学, 医学部, 助教 (60324159)
OZAWA Daisaku 福井大学, テニュアトラック推進本部, 助教 (60554524)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アミロイドーシス / 細胞毒性 / β2-ミクログロブリン / 血液透析 / β2ミクログロブリン / 透析アミロイドーシス / β2‐ミクログロブリン / アミロイド線維 |
|---|
| Research Abstract |
To reveal the way that deposition of β2-microglobulin (β2-m) amyloid fibrils in dialysis related amyloidosis induce bone and articular destruction, we investigated the cytotoxicity of β2-m amyloid fibrils to rabbit synovial fibroblasts. Necrosis and apoptosis of rabbit synovial fibroblasts were induced when β2-m amyloid fibrils were added to the culture medium. This result suggests that direct cytotoxicity of β2-m amyloid fibrils to synovial cells may involve the pathogenesis in bone a nd articular destruction by deposition of β2-m amyloid.
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