| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Research Abstract |
We first described widely distributed normal-lookingneuroendocrine (NE) cells showing isolated/scattered, clustered and/or circumferentialemerging patterns in background tissues of some breast NE tumors (B-NET) including NEductal carcinoma in situ (NE-DCIS). These novel findings could be regarded asrepresenting “NE cell hyperplasia” relevant to B-NET development as a precancerouslesion. In addition, we reported low-grade B-NET closely associated with intraductalpapilloma and high-grade B-NET containing conventional in situ ductal carcinoma foci.Thus, we have shown that multiple mechanisms are involved in the development of B-NET.
|
