Pathological analyses of developmental mechanisms and proposal fora new breast neuroendocrine tumor (B-NET) classification
Project/Area Number |
23790394
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human pathology
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Research Institution | University of Yamanashi |
Principal Investigator |
KAWASAKI Tomonori 山梨大学, 大学院・医学工学総合研究部, 助教 (90456484)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 泌尿生殖器 / 内分泌 / 乳癌 / 神経内分泌癌 (NEC) / 神経内分泌腫瘍 (NET) / 神経内分泌型非浸潤性乳管癌 (NE-DCIS) |
Research Abstract |
We first described widely distributed normal-lookingneuroendocrine (NE) cells showing isolated/scattered, clustered and/or circumferentialemerging patterns in background tissues of some breast NE tumors (B-NET) including NEductal carcinoma in situ (NE-DCIS). These novel findings could be regarded asrepresenting “NE cell hyperplasia” relevant to B-NET development as a precancerouslesion. In addition, we reported low-grade B-NET closely associated with intraductalpapilloma and high-grade B-NET containing conventional in situ ductal carcinoma foci.Thus, we have shown that multiple mechanisms are involved in the development of B-NET.
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Report
(3 results)
Research Products
(191 results)
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[Journal Article] Expression of MHCClass I on breast cancer cellscorrelates inversely with HER2expression2012
Author(s)
Inoue M, Mimura K, Izawa S, ShiraishiK, Inoue A, Shiba S, Watanabe M,Maruyama T, Kawaguchi Y, Inoue S,Kawasaki T, et al
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Journal Title
OncoImmunology
Volume: 1
Pages: 1104-10
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Peer Reviewed
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[Presentation] 乳癌遺伝カウンセリング外来を開設して2012
Author(s)
井上慎吾, 井上正行, 丸山孝教, 井上亜矢子, 北橋敦子, 小俣秀雄, 松田啓, 藤井秀樹, 川崎朋範
Organizer
第20回日本乳癌学会学術総会
Place of Presentation
熊本
Year and Date
2012-06-28
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[Presentation] 卵巣移行上皮癌の一例2012
Author(s)
石井喜雄,弓納持勉,中澤久美子,吉田広美,川崎朋範ら
Organizer
第27回日本臨床細胞学会山梨県支部学術集会
Place of Presentation
山梨
Year and Date
2012-02-04
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[Presentation] 乳腺管状癌の 2 例2011
Author(s)
井上亜矢子, 井上慎吾, 丸山孝教, 井上正行, 川崎朋範ら
Organizer
第73回日本臨床外科学会総会
Place of Presentation
東京都
Year and Date
2011-11-17
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[Presentation] 高齢者乳癌の検討2011
Author(s)
井上正行, 井上慎吾, 井上亜矢子, 丸山孝教, 松田啓, 川崎朋範ら
Organizer
第19回日本乳癌学会学術総会
Place of Presentation
仙台
Year and Date
2011-09-02
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