Elucidation of the effects of matrix metalloproteinase-9 on atherosclerotic plaque rupture in transgenic rabbits
| Project/Area Number |
23790395
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KANG Dedong 山梨大学, 医学工学総合研究部, 助教 (00571952)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 動脈硬化 / ＭＭＰ / ウサギ / MMP-9 |
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| Research Abstract |
Matrix metalloproteinase (MMP) is an important mediator to modulate cell differentiation, proliferation and migration through digestion of extracellular matrix. In pathological conditions, increased expression of MMPs may be involved in many diseases such as atherosclerosis. In our previous study, we have demonstrated that increased expression of MMP-9, agelatinase, may be associated with the development of atherosclerosis and plaque rupture. While this hypothesis is interesting, there are still no suitable animal modes by which one can prove this. In the current study, we attempted to examine the hypothesis whether increased expression of macrophage-derived MMP-9 may be involved in atherosclerosis and plaque rupture. For doing so, we first generated transgenic rabbits which expressed high levels of MMP-9 in macrophages.Now, we have bred these Tg rabbits and are currently performing the cholesterol-fed experiments.
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Report
(4 results)
Research Products
(8 results)
