Technological research and applied analysis of genomic instability in tumor-susceptible individuals
| Project/Area Number |
23790396
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
KAHYO Tomoaki 浜松医科大学, 医学部, 助教 (40416665)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 分子病理 / 腫瘍 / ゲノム解析 / トランスポゾン / HERV / 挿入多型 / 肺腺がん / ゲノム不安定性 / 肺癌 / 多型 / PCR |
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| Research Abstract |
The inverse PCR method targeting the long terminal repeat (LTR) region conserved among human endogenous retroviruses (HERVs) was performed to assess genomic instability in tumor-susceptible individuals. As a result, two novel insertional polymorphisms of solo LTR were identified . Interestingly , one of the two insertional polymorphisms, located on chromosome 1p13.2, was involved with the susceptibility to lung adenocarcinoma of female never-smokers in an age-dependent manner. Further study of epigenetic effects on the LTR region will be necessary
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Report
(3 results)
Research Products
(7 results)
