| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
To identify cancer initiating cells (CICs) in malignant lymphoma, aldehyde dehydrogenase (ALDH) activities and degradation capability of reactive oxygen species (ROS), which have been reported to contain many CICs in several cancers, was examined in Hodgkin lymphoma cell lines. ROS-low and ALDH-high single-nucleated small sized cells formed colonies and tumors more efficiently than ROS-high and ALDH-low cells, respectively. The expression of FoxO3a, a transcription factor regulating ROS-degrading enzymes, was higher in both ROS-low and ALDH-high populations than in ROS-high and ALDH-low populations. These findings suggest that such cells might play an important role in tumorigenesis of Hodgkin lymphoma.
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