Investigation into the relationship between prognosis and characteristics of macrophages in malignant lymphomas
Project/Area Number |
23790398
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Human pathology
|
Research Institution | Osaka University |
Principal Investigator |
WADA Naoki 大阪大学, 医学系研究科, 助教 (80521731)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 血液 / 悪性リンパ腫 |
Research Abstract |
Immunohistochemical double staining with antibodies for HLA-DR/CD68 (markers for M1-tumour-associated macrophage [M1-TAM]) or CD163/CD68 (M2-TAM) was performed to investigate the significance of TAMs in diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL). In DLBCL, a higher number of M2-TAM was a significant factor for poor prognosis. The overall survival rate of the patients with DLBCL-IF, DLBCL showing an interfollicular pattern of proliferation preserving lymphoid follicles, was significantly better than those withDLBCL control group. All DLBCL-IF patients with a low M2-TAM count were alive at the end of observation. In HL, a higher number of M2-TAM was significantly correlated with shorter overall survival. When confined to mixed cellularity subtype of HL, a higher number of M1-TAM was significantly correlated with favorable prognosis.
|
Report
(3 results)
Research Products
(5 results)